ST Segment Elevation Myocardial Infarction
Conditions
Keywords
STEMI, Cardiac magnetic resonance, pharmaco-invasive
Brief summary
The study intends to provide important data on whether the noval method using quantitative flow ratio could predict microvascular dysfunction.
Detailed description
Microvascular dysfunction (MVD) is a serious complication of PCI, which happens frequently after STEMI and always correlates with a poor prognosis. However, precise and simplified assessment of MVD is difficult, especially in the acute phase of STEMI patients. Resent studies suggested that FFR could be overestimated when MVD exists. But whether the overestimated value of FFR caused by CMR defined MVO could reflect microcirculation function is still unclear. This study is a retrospective study using STEMI patients who underwent pharmaco-invasive strategy as the population. Contrast-enhanced CMR was performed 5 days after PCI as the reference standard.
Interventions
DIAGNOSTIC_TESTComputation of quantitative flow ratio
Computation of QFR was performed offline, using AngioPlus system(Pluse medical imaging technology, Shanghai, China). In the first step, 2 diagnostic angiographic projections before PCI, at least 25° apart, were selected and 3D reconstruction of the interrogated vessel without its side branches was performed. Then, the software computed the QFR.
Sponsors
RenJi Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* STEMI patients treated with revasculation within 12 hours from onset of symptoms to PCI time and received CMR 5 days afterwards. STEMI was defined as a combination of the following: chest pain for more than 30min, electrocardiographic (ECG) changing with ST segment elevation of \>2 mm in at least 2 precordial leads and \>1 mm in limb leads, and abnormal troponin levels or CKMB levels higher than twice the upper limit of normal. * Patients underwent successfully pharmaco-invasive strategy with half-dose alteplase.
Exclusion criteria
* Patients with left bundle branch block in the presenting ECG, cardiogenic shock, PCI or bypass surgery history. * Patients with residual stenosis \<50%. * Patients with unqualified coronary angiographic images with problems such as ostial lesion, severe vessel tortuosity and diffuse long lesions.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cardiac magnetic resonance (CMR) | Five days after PCI | Cardiac magnetic resonance (CMR) is a non-invasive test for MVO assessing |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| TIMI Flow Grade (TFG) | One mins before PCI | TIMI Flow Grade (TFG) assesses flow in the epicardial arteries. Type zero perfusion expressed not antegrade movement away the occlusion; type two is a minimum, inadequate perfusion of contrast average round the mass; type three (partial perfusion) is a perfect just limited perfusion from the distal coronary bed by contrast element; and type three (complete perfusion) is an antegrade movement to the whole distal artery at a regular flow. |
| TIMI Myocardial Perfusion Grade (TMPG) | One mins before PCI | TIMI Myocardial Perfusion Grade (TMPG) assesses flow in the micrevessels. TMPG0: no or minimal blush; TMPG1: Stain present Blush persists on next injection; TMPG2: Dye strongly persistent at end of washout Gone by next injection; TMPG3: normal ground glass appearance of blush Dye mildly persistentat end of washout. |
Countries
China
Contacts
Primary ContactJun Pu, MD,PhD
Outcome results
None listed