A Prospective Cohort of Pulmonary Ground Glass Nodules Patients With Family History.

Clinical Database and Biobank of Pulmonary Ground Glass Nodules Patients With Family History, a Prospective Cohort Study.

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04220268

Acronym

GGN-F

Enrollment

600

Registered

2020-01-07

Start date

2020-01-05

Completion date

2022-01-31

Last updated

2020-01-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Family Research, Lung Neoplasms

Keywords

Ground glass nodule, Family aggregation, Hereditary susceptibility

Brief summary

The aim of the present prospective cohort study (GGN-F) is to study the family aggregation of pulmonary ground glass nodules via the questionnaire survey and to investigate the underlying genetic mechanism via the biobank.

Detailed description

In recent years, with the development of low-dose chest CT screening, more and more ground glass nodules have been found. Meanwhile, presenting as Ground-glass nodule (GGN), the early-stage lung adenocarcinoma patients with lung cancer family history have been emerging increasing in recent years in East Asian. This prospective cohort study, with both a cross-sectional and a longitudinal part, will include patients with pulmonary ground glass nodule, which were proven malignant disease. All participants will be asked to complete questionnaire to build the clinical database of GGN patients with detailed family history. Furthermore, blood and surgical tumor samples will be collected as a specific biobank. And the blood samples of other family members of participants will be collected, with their consent and knowledge.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

1. patients with informed consent; 2. patients with pulmonary ground glass nodule. 3. pathological proved early stage lung cancer.

Exclusion criteria

1.not included in the inclusion criteria

Design outcomes

Primary

Measure	Time frame	Description
The prevalence of family aggregation of pulmonary ground glass nodule.	1 week	To investigate the aggregation of pulmonary ground glass nodule among first-degree relatives of participants via the questionnaire.

Secondary

Measure	Time frame	Description
Susceptibility genetic events related to the family aggregation of ground glass nodules.	1 month	To investigate the underlying susceptibility genetic loci which concern with familial inheritance of ground glass nodule.

Countries

China

Contacts

Primary ContactJia-Tao Zhang, Ph.D

18820792959@163.com+86-83827812-51311

Backup ContactRui Fu, MD

13rfu@stu.edu.cn+86-83827812-51311

Outcome results