Schizophrenia
Conditions
Brief summary
This study is designed to find quantitative Electroencephalogram(qEEG) biomarkers to predict Electroconvulsive Therapy(ECT) Response in Schizophrenia
Detailed description
The purpose of this proposal is to explore quantitative Electroencephalogram(qEEG) biomarkers that would predict Electroconvulsive Therapy(ECT) Response in Schizophrenia (SZD). The investigators will recruit 30 SZD patients who are preparing for ECT treatment and assesse psychotic symptoms using Positive and Negative symptom scale(PANSS) before and after 8-sessions clinical course of ECT treatment. These patients needed ECT treatment are assessed by clinicians according to American Psychiatric Association(APA) guidelines. Meanwhile resting EEG will be recorded for 10 minutes before the first episode of ECT treatment. Decrease of PANSS scores will be calculated after the last session of ECT treatment to distinguish responder/non-responder.
Interventions
PROCEDUREElectroconvulsive therapy(ECT)
Patients recieve 8-sessions ECT treatments and those kinds of drugs they take since they were recruited remain unchanged during this study.
Sponsors
Shanghai Mental Health Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* DSM-5 criteria for SZD * patients needed ECT treatment assessed by clinicians using American psychological Association(APA) guidelines. * symptoms must be of at least moderate severity (PANSS score \>71) * age between 18 to 60 years old * medications will be stable for at least four weeks prior to ECT, and there will be no dose changes unless medically necessary
Exclusion criteria
* any additional current psychiatric comorbidity * pregnancy or prepare to have a baby * current use of any Antiepileptic drugs * history of taking any kinds of Physicotherapeutics within 6 months * severe psychotic symptoms that make patients could not accomplish the clinical interview
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Positive and negative syndrome scale（PANSS）score | up to 4 weeks | It assessed the severity of psychotic symptoms.The responder on PANSS is defined as a PANSS decrease at least 25% from the baseline at post-treatment. PANSS helps us divide cases into response and nonresponse group. |
| EEG functional connectivity difference between response and nonresponse group | through study completion, an average of 6 months | This is a predictive indicator collected before ECT treatment. After treatment, we divided 30 patients into response and nonresponse group using PANSS. Then we explore differences in pretreatment EEG functional connectivity at different frequency bands (Alpha, Beta, Delta, and Theta) to find a predictable biomarker for ECT treatment effect. |
Countries
China
Outcome results
None listed