IgG-4 Levels in Systemic Sclerosis

Comparing IgG-4 Levels in Systemic Sclerosis Patients vs. Healthy Controls

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04219592

Acronym

SSc-IgG4

Enrollment

154

Registered

2020-01-07

Start date

2019-05-30

Completion date

2024-10-30

Last updated

2025-05-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Systemic Sclerosis

Keywords

SSc, IgG4

Brief summary

This is an observational - non interventional study. The investigators will compare IgG4 levels of 80 healthy donors (from Israel blood bank - MDA) and 80 Systemic Sclerosis patients from Meir Medical Center.

Detailed description

IgG4 levels will be obtained from medical records of 80 SSc patients between the years 2000-2019. These will be compared to IgG4 levels from sera of 80 healthy donors (from Israel blood-bank - MDA). Correlations between IgG4 levels and the following will be made: age, sex, disease type (limited or diffused SSc), disease duration, medications.

Interventions

DIAGNOSTIC_TESTIgG4 measurement (non-interventional, just obtaining data from medical records)

IgG4 measurement in mg/dL

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 85 Years

Healthy volunteers

Yes

Inclusion criteria

* SSc patients

Exclusion criteria

* other chronic co-morbidities

Design outcomes

Primary

Measure	Time frame	Description
IgG4 measurement	4 months	quantifying IgG4 in each group and in SSc subgroups based on disease type, organs involved, medications.

Countries

Israel

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026