Critical Illness
Conditions
Keywords
Critical Illness Related Cardiac Arrest
Brief summary
CIRCA aims to determine the incidence and outcomes of in-hospital cardiac arrest (IHCA) in UK intensive care units (ICUs) and explore associated risk factors with ICU and hospital survival and quality of survival following hospital discharge.
Detailed description
Cardiac arrest is often categorised by location, out-of-hospital or in-hospital (IHCA), as there are important differences in population characteristics and aetiology. The National Cardiac Arrest Audit (NCAA) was established to audit resuscitation teams in response to IHCA, and collects information about patient characteristics, resuscitation processes, and patient outcomes. However, it does not audit IHCAs that are not attended by the resuscitation team. Critically ill patients managed in ICUs are experiencing failure of one or more organs and therefore more intensive and invasive therapies are needed to support these failing organs. As a result, ICUs have higher nursing and medical staffing ratios, and monitoring is usually continuous. Moreover, the skill mix of the multidisciplinary team is geared to advanced life support. Thus, the risk of cardiac arrest occurring, the involvement (or not) of the resuscitation team, and the probability of return of spontaneous circulation are all likely to be different to other IHCAs. Accurate data on cardiac arrests in ICU are lacking and the investigators do not know how many IHCA occur in ICU in the UK, nor is the impact of an IHCA in ICU on outcome known. In addition, it is not known if these IHCAs in ICUs represent an unavoidable consequence of critical illness or, more importantly, whether they can be predicted and/or prevented. CIRCA is a prospective, multi-centre observational cohort study nested in the Case Mix Programme (CMP) and NCAA national clinical audits. The investigators aim to determine the incidence and outcomes of IHCA in UK ICUs and explore associated risk factors with ICU and hospital survival and quality of survival following hospital discharge.
Interventions
None listed
Sponsors
North Bristol NHS Trust
Intensive Care National Audit & Research Centre
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
1. Age 18 years old or more; and either 2. Cardiac arrest (defined as receipt of chest compressions or defibrillation) occurring while in-hospital and within intensive care (defined as either ICU, HDU or combined ICU/HDU); or 3. Family member of a patient surviving to discharge from intensive care after a cardiac arrest within ICU
Exclusion criteria
There are no
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence | Up to 12 months | Incidence of critical illness related cardiac arrest |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Survival status at hospital discharge | Up to 12 months | Survival status at hospital discharge obtained from data linkage to the Case Mix Programme |
| Survival status at 12 months | 12 months | Survival status at 12 months obtained from data linkage to NHS Digital |
| Patient quality of life measured through EQ-5D-5L questionnaire completion at 3 months | 3 months | Patient quality of life measured through completion of EuroQol 5 Dimension (5 level) questionnaire at 3 months following critical illness related cardiac arrest |
| Patient quality of life measured through EQ-5D-5L questionnaire completion at 6 months | 6 months | Patient quality of life measured through completion of EuroQol 5 Dimension (5 level) questionnaire at 6 months following critical illness related cardiac arrest |
| Patient quality of life measured through EQ-5D-5L questionnaire completion at 12 months | 12 months | Patient quality of life measured through completion of EuroQol 5 Dimension (5 level) questionnaire at 12 months following critical illness related cardiac arrest |
| Subsequent incidence of in-hospital cardiac arrest | Up to 12 months | Subsequent incidence of in-hospital cardiac arrest obtained through data linkage to the National Cardiac Arrest Audit |
| Patient quality of life measured through IQCODE questionnaire completion at 6 months | 6 months | Patient quality of life measured through completion of Informant Questionnaire on Cognitive Decline in the Elderly questionnaire at 6 months following critical illness related cardiac arrest |
| Patient quality of life measured through IQCODE questionnaire completion at 12 months | 12 months | Patient quality of life measured through completion of Informant Questionnaire on Cognitive Decline in the Elderly questionnaire at 12 months following critical illness related cardiac arrest |
| Family member quality of life measured through FROM-16 questionnaire completion at 3 months | 3 months | Quality of life of family member of patients surviving critical illness related cardiac arrest measured through completion of Family Reported Outcome Measures 16 questionnaire at 3 months following patient arrest |
| Family member quality of life measured through FROM-16 questionnaire completion at 6 months | 6 months | Quality of life of family member of patients surviving critical illness related cardiac arrest measured through completion of Family Reported Outcome Measures 16 questionnaire at 6 months following patient arrest |
| Family member quality of life measured through FROM-16 questionnaire completion at 12 months | 12 months | Quality of life of family member of patients surviving critical illness related cardiac arrest measured through completion of Family Reported Outcome Measures 16 questionnaire at 12 months following patient arrest |
| Patient quality of life measured through IQCODE questionnaire completion at 3 months | 3 months | Patient quality of life measured through completion of Informant Questionnaire on Cognitive Decline in the Elderly questionnaire at 3 months following critical illness related cardiac arrest |
Countries
United Kingdom
Contacts
Primary ContactDoug Gould
Backup ContactRobert Darnell
Outcome results
None listed