Aging, EEG With Periodic Abnormalities, Postoperative Cognitive Dysfunction
Conditions
Keywords
noncardiac surgery, elderly patients, postoperative cognitive dysfunction, Electroencephalogram
Brief summary
In the elderly patients undergoing elective non-cardiac major surgery, the differences of EEG parameters between those with and without postoperative cognitive dysfunction were observed to determine the characteristic changes of EEG parameters related to postoperative cognitive dysfunction
Interventions
OTHEREEG(Electroencephalogram) change
patients are found to have characteristic EEG change
Sponsors
Air Force Military Medical University, China
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
1. aged 65 and above 2. non-cardiac surgery under general anesthesia; 3. American Society of Anesthesiology(ASA) classification I- II 4. Patients aged 18-40 years old are set as background
Exclusion criteria
1. patients with central nervous system diseases and mental diseases 2. preoperative minimal mental status examination(MMSE) score\<24; 3. ASA status III or higher 3\) those who have received less than 5 years of education since entering primary school; 4) history of sedatives or antidepressants use; 5) existed or anticipated alcohol or drug abuse(over 40°c and over 100ml per day for the past 3 months); 6) history of surgery within the previous year; 7) those with severe visual or hearing impairment; 8) those participated in other clinical studies within last 3 months;
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The difference of delta wave miss rate between patients with or without cognitive dysfunction by 1 day after surgery | from end of surgery to 1 day after surgery | The difference (OR) between the miss rate of delta wave in patients with and without cognitive function change 1 day after operation. |
| The difference of spindle miss rate between patients with or without cognitive dysfunction by 1day after surgery | from end of surgery to 1 day after surgery | The difference (OR) between the miss rate of spindle in patients with and without cognitive function change 1 day after operation. |
Secondary
| Measure | Time frame |
|---|---|
| The difference of burst suppression rate between patients with or without cognitive dysfunction by 3 days after surgery | from end of surgery to 3 days after surgery |
| correlation of delta wave miss rate and incidence of postoperative cognitive dysfunction by 1 day after surgery | from end of surgery to 1 day after surgery |
| correlation of delta wave miss rate and incidence of postoperative cognitive dysfunction by 3 days after surgery | from end of surgery to 3 days after surgery |
| correlation of spindle miss rate and incidence of postoperative cognitive dysfunction by 1d after surgery | from end of surgery to 1d after surgery |
| correlation of spindle miss rate and incidence of postoperative cognitive dysfunction by 3 days after surgery | from end of surgery to 3 days after surgery |
| The difference of delta wave miss rate between patients with or without cognitive dysfunction by 3 days after surgery | from end of surgery to 3 day after surgery |
| correlation of burst suppression rate and incidence of postoperative cognitive dysfunction by 3 days after surgery | from end of surgery to 3 days after surgery |
| correlation of burst suppression rate and incidence of death by 30 days after surgery | from end of surgery to 30 days after surgery |
| correlation of delta wave miss rate and incidence of death by 30 days after surgery | from end of surgery to 30 days after surgery |
| correlation of spindle miss rate and incidence of death by 30 days after surgery | from end of surgery to 30 days after surgery |
| correlation of burst suppression rate and incidence of postoperative cognitive dysfunction by 1 day after surgery | from end of surgery to 1 day after surgery |
| The difference of spindle miss rate between patients with or without cognitive dysfunction by 3 days after surgery | from end of surgery to 3 days after surgery |
Countries
China
Contacts
Primary ContactHailong Dong
Backup ContactZhihong Lu
Outcome results
None listed