A Study on the Effect of Platelet Rich Plasma (PRP) on Osteoarthritis in the Thumb Base

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04218591

Enrollment

Registered

2020-01-06

Start date

2020-02-24

Completion date

2023-12-31

Last updated

2024-01-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thumb Osteoarthritis

Brief summary

Randomized comparison between Platelet Rich Plasma (PRP) and placebo (Saline) for thumb base.osteoarthritis.

Interventions

OTHERPRP

Platelet rich plasma

OTHERPlacebo

Saline

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Arthritis in the thumb base. * Radiological Eaton Littler class 1-3. * Clinical signs of thumb base osteoarthritis: pain at palpation of the CMC-1 joint and pain during provocation/grinding test.

Exclusion criteria

* Rheumatoid arthritis. * Ongoing infection in the hand or wrist. * History of gout or pseudo gout. * Inability to co-operate with the follow-up protocol (language difficulties, severe psychiatric disorder, cognitive impairment, drug addiction). * Intra-articular injection in the affected joint within 6 months. * Eaton Littler class 4 (STT joint involved).

Design outcomes

Primary

Measure	Time frame	Description
Change in patient-rated pain on load	3 and 6 months after injection.	Numerical rating scale 0-10p (10=worst possible pain).

Secondary

Measure	Time frame	Description
Change in EQ-5D	3 and 6 months after injection.	Weight mean value: 0=dead, 1= healthy
Change in Patient-rated Wrist and Hand Evaluation (PRWHE)	3 and 6 months after injection.	Patient Rated Outcome Measure 0-100p, higher score=more disability
Change in Disability of the Hand, Arm and Shoulder (DASH) score	3 and 6 months after injection.	Patient Rated Outcome Measure, 0-100p higher score=more disability
Change in Nelson Thumb score	3 and 6 months after injection.	Patient Rated Outcome Measure, 0-100p, lower score= more disability
Change in Pain Catastrophizing Score (PCS).	3 and 6 months after injection.	0-52p, higher score = more pain catastrophizing
Change in thumb range of motion	3 and 6 months after injection.	Radial and palmar abduction of the first metacarpal (degrees)
Change in thumb strength	3 and 6 months after injection.	Key pinch and pinch strength (Kg)
Change in Hospital Anxiety and Depression Score (HADS),	3 and 6 months after injection.	2 subscores for anxiety (0-21p) and depression (0-21p), higher score = worse

Countries

Sweden

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026