Contact Dermatitis of Hands
Conditions
Keywords
Occupational Hand Dermatitis, Moisturizer, Niacinamide, Virgin coconut oil, HECSI, TEWL, SCap
Brief summary
Occupational hand dermatitis (OHD) often occurs in intensive care unit (ICU) nurses, especially in individuals who are vulnerable due to irritant exposure e.g. hand rub alcohol and repeated hand washing activities. The use of moisturizer is one of the recommendations for skin care in OHD. Niacinamide which has anti-inflammatory effects and can improve the skin barrier function. Virgin coconut oil (VCO) is rich in lipids and lauric acid, and has an occlusive effect. Until now there are no guidelines and reference types of moisturizers for secondary prevention in DTAK.
Detailed description
The aim of this study is identify the effectiveness and safety between moisturizing cream containing niacinamide 4% and VCO 30% for secondary prevention of occupational hand dermatitis in ICU nurses This study also measured HECSI , TEWL, and SCap before and after treatment
Interventions
OTHERNiacinamide 4%
cream moisturizer
OTHERVirgin Coconut oil 30%
cream moisturizer
Sponsors
Indonesia University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Masking description
Both moisturizers have the same physical characteristics, with the same color and odor. Randomization was carried out by other than researcher (statistical adviser)
Intervention model description
There were 46 subjects in the niacinamide 4% arm and 46 subjects in the VCO 30% arm
Eligibility
Sex/Gender
ALL
Age
18 Years to 58 Years
Healthy volunteers
No
Inclusion criteria
ICU nurses who: * Sign the informed consent of the study after receiving explanation before all activity related with this study begin. * Has Occupation Hand Dermatitis that fulfill the Mathias criteria with dermatitis severity mild to moderate which the score is 1, 2 or 3 corresponding with Investigator Global Assesment (IGA) * Agree to follow the study protocol
Exclusion criteria
* History of allergic or irritate by Niacinamide or VCO or other component in moisturizer * Receiving medium to high potency of topical Corticosteroid or systemic immunosupresant therapy or history of oral corticosteroid therapy in the last 1 month
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| HECSI | 14 days | Hand eczema severity index (HECSI) is a score to indicate the severity of hand dermatitis. The range of HECSI score is 0-360. The HECSI score before treatment was expected to be higher than after treatment. Outcome: change of HECSI |
| TEWL | 14 days | Trans Epidermal Waterloss (TEWL) is the primary parameter which measured for the skin barrier function, when the skin barrier is damaged the skin will be disrupted in maintaining water. Passive water diffusion via the Corneal stratum. TEWL is measured in g/h/m2. The TEWL value before treatment was expected to be higher than after treatment. Outcome: change of TEWL |
| SCap | 14 days | Skin Capasitance (SCap) is a score for skin hidration. SCap can be done with measuring the water level in corneal stratum using non-invasive electric method which measure the capacitance. SCap is measured in Arbitrary Unit (AU). SCap value before treatment was expected to be lower than after treatment. Outcome: change of SCap |
Countries
Indonesia
Outcome results
None listed