Deprivation Amblyopia
Conditions
Brief summary
The aim of this study is to quantify and compare the foveal avascular zone (FAZ), the parafoveal and foveal vessel density of superficial (SCP) and deep capillary plexus (DCP) and retinal thickness in deprivation amblyopic eyes, fellow non-amblyopic eyes, and age-matched normal eyes, using optical coherence tomography angiography (OCTA). The FAZ, parafoveal and foveal SCP and DCP, and retinal thickness were measured in normal controls and at least 3 months postoperatively in children with unilateral cataract and compared between groups after adjusting for axial length and spherical equivalents.
Interventions
DEVICEOptical Coherence Tomography Angiography
A device testing the vascular density in the retina
Sponsors
Wenzhou Medical University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
3 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* children after cataract surgery and healthy volunteers
Exclusion criteria
* presence of corneal opacity preventing detailed imaging * nystagmus * retinal disease, * persistent fetal vasculature * intraocular inflammation, * glaucoma * vitreoretinal surgery * premature birth * neurologic disease * systemic disease that could alter microvasculature (including diabetes, hypertension, cardiovascular disease and renal disease)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Foveal retinal thickness | up to 36 months | Foveal retinal thickness in microns |
| Area of foveal avascular zone | up to 36 months | Area of foveal avascular zone in square microns |
Countries
China
Contacts
Primary ContactZhangliang Li, MD
Outcome results
None listed