Magnesium Deficiency
Conditions
Keywords
Magnesium, Supplementation, Interleukin-6, Soluble interleukin-6 receptor, Glucose, Pain, Exercise performance, Exercise recovery, Downhill running
Brief summary
This study investigated the effect of magnesium supplementation on exercise performance and functional recovery in recreational endurance athletes in conjunction with measures of blood glucose, lactate, IL-6 and sIL-6R.
Detailed description
Magnesium status can directly affect circulating glucose concentrations both during and post exercise. In addition, magnesium supplementation has been shown to reduce circulating IL-6 concentrations post exercise in humans. It is conceivable that such observations are linked through the role of IL-6 in glucose regulation, possibly in combination with sIL-6R. Together, magnesium intake may have the potential to effect exercise performance and recovery through glucose availability. This in turn may be connected to the production of IL-6 and sIL-6R which have been established to influence exercise fatigue and perception of pain (muscle soreness).
Interventions
DIETARY_SUPPLEMENTMagnesium oxide
Magnesium capsule
DIETARY_SUPPLEMENTPlacebo
Cornflour capsule manufactured to mimic the 166.6 mg magnesium capsule.
Sponsors
Beijing Sport University
Coventry University
University of Worcester
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
MALE
Age
20 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Regular recreational runner, running around 3 times per week * Capable of running 10 km in \ 40 minutes.
Exclusion criteria
* Any signs or symptoms of cardiovascular issues. * Any recent form of injury or illness. * Currently, or in the last 3 months, have consumed multivitamin supplements * Currently, or in the last 3 months, have consumed anti-inflammatory medications.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Downhill 10 km treadmill time trial performance | 1 day | Maximal 10 km time trial performance on a treadmill |
| 24 hr post exercise maximal force testing of the dominant leg on the isokinetic dynamometer | 1 day | Maximal force produced from the dominant leg (eccentric and concentric) on an isokinetic dynamometer. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Soluble interleukin-6 receptor | up to 2 days | Venous blood samples at rest, immediately post, 1hr post and 24 hrs 10 km downhill time trial. Enzyme-linked immunosorbent assays were used to analyse soluble interleukin-6. |
| Perceived muscle soreness | up to 4 days | A 10cm visual analogue scale was used to assess perceived muscle soreness, the scale started at 0 (no pain) and finished at 10 (unbearable pain) |
| Glucose | up to 2 days | Capillary blood samples at rest, during, immediately post, 1 hr post and 24 hrs post 10 km downhill time-trial. A Biosen analyser was used to analyse glucose concentrations. |
| Creatine kinase | up to 2 days | Venous blood samples at rest, immediately post, 1hr post and 24 hrs 10 km downhill time trial. A Reflotron analyser was used to analyse creatine kinase concentrations. |
| Lactate | up to 2 days | Capillary blood samples at rest, during, immediately post, 1 hr post and 24 hrs post 10 km downhill time-trial. A Biosen analyser was used to analyse lactate concentrations. |
| Interleukin-6 | up to 2 days | Venous blood samples at rest, immediately post, 1hr post and 24 hrs 10 km downhill time trial. Enzyme-linked immunosorbent assays were used to analyse interleukin-6. |
Countries
United Kingdom
Outcome results
None listed