HIV-infection/Aids, NAFLD
Conditions
Keywords
HIV infection, NAFLD
Brief summary
The prevalence of NAFLD (nonalcoholic fatty liver disease) in HIV-infected patients is higher than that in general population, but the causes of morbidity and pathogenesis have not been fully explored. The investigators are planning to consecutively enroll 400 cases HIV-positive outpatients, and to detect NAFLD by ultrasound. The fecal and blood samples were also collected to explore the mechanism of NAFLD. The investigators aimed to determine the prevalence and risk factors of NAFLD in HIV infected patients.
Interventions
OTHERNo intervention; cross-sectional study
No intervention; cross-sectional study
Sponsors
Shanghai Public Health Clinical Center
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Age 18\ 70 y; * HIV-positive patients; * written the informed consent
Exclusion criteria
* coinfected with HBV, HCV; * secondary causes of fatty liver (eg, consumption of amiodarone and tamoxifen) and decompensated liver disease; * significant alcohol consumption (\>20 g per day for man, \>10 g per day for woman); * received antibiotics in preceding two months; * autoimmune disease; * severe heart, lung, kidney, brain, blood diseases or other important systemic diseases; * pregnant or lactating women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| morbidity of nonalcoholic fatty liver disease | 1 month | NAFLD was diagnosed using ultrasound |
Countries
China
Contacts
Primary ContactHongzhou Lu, Ph.D
Backup ContactHongzhou Lu, PI
Outcome results
None listed