Lung Cancer
Conditions
Keywords
PSC, Integrative Analysis, IHC, WES, RNA sequencing
Brief summary
Integrative Analysis of pulmonary sarcomatoid carcinoma (PSC)
Detailed description
The investigators will analyzed proteomes of paired normal lung tissues and pulmonary sarcomatoid carcinoma with or without metastasis, sequenced transcriptomes, perform whole exome sequencing, and single nucleotide polymorphism (SNP) array profiling for triplets, each comprising normal lung tissue, primary pulmonary sarcomatoid carcinoma, and its synchronous matched metastasis, as well as analyzed genomics of lung cancer characterized previously by The Cancer Genome Atlas (TCGA) to conduct integrated proteogenomic analyses.
Interventions
OTHERThe investigators will extract total protein, DNA and RNA from PSC patients.
The investigators will extract total protein, DNA and RNA from PSC patients.
Sponsors
The Affiliated Tumor Hospital of Nantong University, Nantong, Jiangsu Province, China
Anhui Medical University
Shanghai 10th People's Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Age ≤ 70 years with histologically proven LCLC * No severe major organ dysfunction * World Health Organization (WHO) performance status of 0 or 1 * No prior cancer chemotherapy
Exclusion criteria
* Age ≥ 70 * Severe major organ dysfunction * WHO performance status of \>1 * Prior cancer chemotherapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 10 years overall survival | 10 years overall survival | 10 years overall survival |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 10 years disease-free survival | 10 years disease-free survival | 10 years disease-free survival |
Countries
China
Outcome results
None listed