Missed Abortion
Conditions
Brief summary
This study compares the success rate of letrozole and misoprostol versus misoprostol alone for medical termination of first-trimester pregnancy among women with one or more previous cesarean deliveries.
Interventions
Drug: Letrozole 2.5mg total dose 7.5 mg per day for 3 days Drug: Misoprostol Misoprosrol 800mcg will be given to all patients for induction of abortion
Drug: Placebo placebo for 3 days Drug: Misoprostol Misoprosrol 800mcg will be given to all patients for induction of abortion
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Gestational age less than 64 days gestation (\<9 wks). * Hemoglobin \>10 g/dL. * BMI between 18.5 kg/m2 and 25 kg/m2. * Missed abortion. * previous one or more cesarean delivaries
Exclusion criteria
* Molar pregnancy. * Fibroid uterus. * Uterine anomalies. * Coagulopathy. * Medical disorder that contraindicate induction of abortion (e.g. heart failure). * Previous attempts for induction of abortion in the current pregnancy. * Allergy to misoprostol or letrozole.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| induction to abortion time | 6 hours | induction to abortion time |
| Incidence of complete miscarriage | 6 hours | Incidence of complete miscarriage |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Need for surgical evacuation of the products of conception | 6 hours | Need for surgical evacuation of the products of conception |
Contacts
Primary ContactAHMED SAMY
Outcome results
None listed