Intracranial; Infection, Psychosis, Acute or Subacute
Conditions
Keywords
Procalcitonin, C-reactive protein, white blood cell count, intracranial infection
Brief summary
Intracranial infection are serious complications postoperatively in neurosurgical patients. Early identification of these complications is essential to minimize the mortality and moribidy. The aim of this study is observe the postoperative dynamic changes of body temperature (BT), procalcitonin (PCT), C-reactive protein (CRP), and white blood cell (WBC) count, and evaluate whether the use of two or more of these markers may improve the diagnostic accuracy of intracranial infection.
Detailed description
Intracranial infection is a serious complications after neurosurgical operation. Early identification of intracranial infection is important so that, first, optimal treatment is initiated which may improves outcome, second, inappropriate antibiotic treatment and subsequent resistance are prevented, and third, it will promote shorter hospitalization and less cost. In several previous studies, the values of procalcitonin (PCT) and C-reactive protein (CRP) in predicting intracranial infection have been evaluated in neurosurgical patients. However, due to the limited number of studies, the results are not convincing enough and more investigations seems warranted to clarify their dynamic changes in neurosurgical patients without intracranial infection and their role in confirming the suspicion of intracranial infection or excluding intracranial infection from the differential diagnosis. The aim of the investigator's study is to observe the postoperative dynamic changes of BT, PCT, CRP, and white blood cell (WBC) count, and evaluate whether the use of two or more of these markers may improve the diagnostic accuracy for rational decisions about antibiotic treatment.
Interventions
DIAGNOSTIC_TESTpostoperative fever, serum procalcitonin, C-reactive protein and white blood cell coun
All patients in Intracranial Infection group were cured with antibiotic treatment
Sponsors
Pan Jun
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 68 Years
Healthy volunteers
Yes
Inclusion criteria
1. craniotomy of brain tumor; 2. no clinical manifestations of infection before operation; 3. no other infection such as respiratory tract infection, urinary tract infection and deep vein catheter infection before the definite diagnosis of intracranial infection ; 4. the patients had informed consent to enter the study.
Exclusion criteria
1. blood system diseases,respiratory tract infection, urinary tract infection and deep vein catheter infection; 2. malignant tumors with neuroendocrine characteristicsr; 3. aspiration, pancreatitis, etc.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the diagnosis of intracranial infection after craniotomy | up to 100 weeks | Intracranial infection are serious complications postoperatively in neurosurgical patients. Early identification of these complications is essential to minimize the mortality and moribidy. The aim of this study is observe the postoperative dynamic changes of body temperature (BT), procalcitonin (PCT), C-reactive protein (CRP), and white blood cell (WBC) count, and evaluate whether the use of two or more of these markers may improve the diagnostic accuracy of intracranial infection |
Countries
China
Contacts
Primary ContactXi'an Zhang, doctor
Backup ContactJunxiang Peng, doctor
Outcome results
None listed