Morbidity;Newborn
Conditions
Brief summary
The aim is to evaluate the impact of a complete course of antenatal steroids treatment on mortality and main morbidities in a current population of preterm infants.
Detailed description
All infants admitted in the Neonatal Department born with less than 32 weeks of gestational age are included. Data are prospectively recorded. Perinatal variables (Gestational age, materna condition at admission, antenatal steroids treatment, gender and results of histological analysis of the placenta) are recorded as well as respiratory status during hospitalization and morbidities at discharge. Results of neurodevelopment test performed at 24 months of corrected age are also included.
Interventions
OTHERObservational study. Postnatal variables are recorded
Postnatal evolution is analyzed in both groups
Sponsors
Hospital General Universitario Gregorio Marañon
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 6 Hours
Healthy volunteers
No
Inclusion criteria
* All infants admitted in the NICU (with less than 6 hours after birth) born with less than 32+0 weeks of gestational age (GA).
Exclusion criteria
* Congenital malformations. * premature infants in whom active resuscitation measures are not established.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mortality | at hospital discharge, an average of 2-4 months. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants with Bronchopulmonary dysplasia (BPD) diagnosis. | 36 weeks postmenstrual age | BPD is considered as type 2 and 3 by consensus definition |
| Number of participants requiring Surfactant administration | in the first 3 days after birth | — |
| Number of participants that requires Mechanical ventilation. | during hospitalization, and average of 2-4 months | — |
| Number of participants with Neurodevelopment disability | performed at 24 months | Scale of Psychomotor Development of Children (the Brunet-Lézine Scale). This scale consists of 150 items that are grouped around the following four areas: Posture (postural control or general motor skills), Coordination (psychomotor coordination), Language (comprehension and expression) and Sociability (social relations). The score of the items is binary (1/0) depending on whether the acquisition evaluated is achieved or not. The development age (ED) is obtained from the sum of the items. The result of dividing the age of development by postmenstrual age is the development quotient (CD). This calculation is practiced both for the set of items on the scale (global development quotient) and for each of the areas (partial development quotients). We have considered the value of the overall development quotient of less than 85 as the limit of normality, since it is a standard deviation below the expected development for its age. |
Countries
Spain
Outcome results
None listed