Head and Neck Cancer Patients Treated With Radiotherapy
Conditions
Brief summary
Aims: 1. To evaluate the effects of radiation therapy on the inner ear, among patients treated with radiation therapy for head and neck cancers using a wide battery of tests (Audiometry and tympanometry, vHIT, VEMP, ENG) ; 2. To correlate the mean total radiation dose to the cochlea with the effects on audiological and vestibular function
Interventions
DIAGNOSTIC_TESTAudiometry and tympanometry, vHIT, VEMP, ENG
Diagnostic tests
Sponsors
Tel-Aviv Sourasky Medical Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Females and males, Age: ≥ 18 years old * Patients diagnosed Head and Neck cancers, not treated previously * Planned for radiation therapy in which the inner ear will be radiated
Exclusion criteria
* Patients who were previously diagnosed with a vestibular disorder * Previous middle or inner ear anomaly * Failure to complete the whole course of radiation therapy * More than one course of radiation therapy * Patients treated with concurrent ototoxic chemotherapy * Pregnant women * Patients who will not sign an informed consent form * Helpless or incompetent patients
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Audiometry | 1.5 Year | The change in hearing threshold and in the speech-audiometry |
| ENG test | 1.5 Year | Abnormal function of the central vestibular pathways, unilateral weakness of the vestibular apparatus or direction preponderance |
| VEMP test | 1.5 Year | Abnormal latencies, amplitudes, thresholds |
| vHIT test | 1.5 Year | abnormal gain, the appearance of overt and covert saccades |
Contacts
Primary ContactYahav Oron, MD
Outcome results
None listed