Ocular Microvascular Changes in Patients With Sepsis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04214743

Enrollment

Registered

2020-01-02

Start date

2018-01-02

Completion date

2019-08-31

Last updated

2020-01-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Conjunctiva; Disorder, Retinal Microcirculation Disorder, Sepsis

Keywords

Conjunctival microcirculation, retinal vessels, fundus imaging, IDF imaging, sepsis

Brief summary

This study evaluates differences in the ocular microcirculation between septic patients and healthy subjects and the course of ocular microvasculature in survivors and non-survivors over a 24 hours period of time in septic patients

Detailed description

Conjunctival imaging, using IDF video microscope, and retinal imaging, using portable digital fundus camera, as well as systemic hemodynamic measurements, were performed in septic patients at three time points: at baseline, 6 hours and 24 hours. Baseline conjunctival and retinal microcirculatory parameters were compared with healthy controls.

Interventions

DEVICEIncident dark field videomicroscope from Braedius

It allows to look at conjunctival microcirculation

DEVICEFundus camera from Optomed

It allows to monitor retinal microvasculature

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* adult patients with sepsis or septic shock within the first 24 hours after ICU admission

Exclusion criteria

* psychiatric disorders, brain diseases, chronic alcoholism, autoimmune rheumatic diseases * ophthalmological diseases, such as glaucoma, age-related macular degeneration, diabetic retinopathy and cataract

Design outcomes

Primary

Measure	Time frame	Description
Microvascular flow index in conjunctival small vessels	24 hours	Differences in MFI in conjunctival small vessels between septic patients and healthy controls and differences between survivors and non-survivors

Secondary

Measure	Time frame	Description
Central retinal arteriolar equivalent of retinal vessels	24 hours	Differences in central retinal arteriolar equivalent of retinal vessels between septic patients and healthy controls and differences between survivors and non-survivors

Countries

Lithuania

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 27, 2026