Single Versus Repeat Betamethasone in Twin Pregnancies

Repeat Versus Single Course of Betamethasone in Twin Pregnancies

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04212312

Enrollment

2000

Registered

2019-12-26

Start date

2020-02-01

Completion date

2021-01-01

Last updated

2019-12-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Twin; Complicating Pregnancy

Keywords

Betamethasone, Twin pregnancy, Repeat course, Single course

Brief summary

Thus far no robust data exist as to the effect of repeted course of antenatal corticosteroids in twin pregnancies. The investigators hypothesized that repeat course of betamethasone would further reduce neonatal morbidity in twins born before 34 weeks' gestation when compared with single dose.

Detailed description

Observational data suggest benefits in multiple gestations exposed to antenatal corticosteroids, although these studies have not consistently reported a statistical benefit or the benefits achieved in singletons. Nevertheless, based on the improved outcomes reported in singleton gestations, one course of antenatal corticosteroids is administered to all patients who are between 24 weeks and 34 weeks of gestation and at risk of delivery within 7 days, irrespective of the fetal number. Moreover, a repeat course of antenatal corticosteroids should also be considered in women who are less than 34 weeks of gestation who have an imminent risk of preterm delivery within the next 7 days, and whose prior course of antenatal corticosteroids was administered more than 14 days previously, again, irrespective of the fetal number. The objective of the current study is to evaluate fetal outcomes in twin pregnancies following repeat betamethasone administration during pregnancy.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Inclusion criteria

* Study group - women who received 2 courses of betamethasone between 24 - 34 weeks' gestation. * Control comparison group - women who received 1 course of betamethasone between 24 - 34 weeks' gestation.

Exclusion criteria

* singletone pregnancies * higher order multiple pregnancies (triplets and above) * known major congenital anomaly

Design outcomes

Primary

Measure	Time frame	Description
The incidence of respiratory morbidity after single versus repeat course of betamethasone for threatened preterm labor between 24-34 weeks' gestation	1 year	The incidence of respiratory morbidity after single versus repeat course of betamethasone for threatened preterm labor between 24-34 weeks' gestation

Countries

Israel

Contacts

Primary ContactYaniv Zipori, M.D

y_zipori@rambam.health.gov.il+972 58 7966963

Outcome results