End Stage Renal Disease
Conditions
Brief summary
An observational cohort study will be conducted to non-invasively investigate central blood pressure and pulse wave velocity in children with kidney disease and controls. Using an oscillometric monitor, the investigators aim to non-invasively obtain the central blood pressure and pulse wave velocity (PWV), or arterial stiffness, of children with kidney disease. The investigators will also enroll age- and race-matched healthy controls and measure the same parameters for comparison. In addition, the investigators will measure PWV by standard arterial tonometry method in a subset of patients.
Detailed description
The specific aims of the study are as follows: 1. Using an oscillometric blood pressure monitor, the investigators aim to non-invasively obtain the central blood pressure and pulse wave velocity (PWV), or arterial stiffness, of children with kidney disease. 2. Measure oscillometric central blood pressure and PWV in age and race matched healthy children. 3. Measure PWV by standard arterial tonometry method in a subset of patients, and compare these measurements to the PWV measured using the oscillometric device. 4. Measure body composition of patients and controls (Body Mass Index, Waist-to-Height ratio, %body fat, and mid-arm muscle circumference) to see how this relates to central blood pressure and PWV.
Interventions
OTHERthere is no intervention
There is no intervention in this study. It is observational only.
Sponsors
Children's National Research Institute
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
3 Years to 21 Years
Inclusion criteria
* kidney transplant recipients who are at least 6 months post-transplant * healthy children matched for age sex and race
Exclusion criteria
* age less than 3 years
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Oscillometric central blood pressure | cross-sectional measurement performed in patients who are between 6 months to 10 years post-transplant | Central blood pressure as measured by oscillometric blood pressure device |
| Oscillometric pulse wave velocity | cross-sectional measurement performed in patients who are anywhere between 6 months to 10 years post-transplant | Pulse wave velocity as measured by oscillometric blood pressure device |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Body mass index (BMI) in kg/m2 | cross-sectional measurement performed in patients who are anywhere between 6 months to 10 years post-transplant | weight measured in kg and height measured in cm will be combined to determine BMI (kg/m2) |
| Waist circumference (cm) | cross-sectional measurement performed in patients who are anywhere between 6 months to 10 years post-transplant | waist circumference will be measured in cm using a flexible tape measure |
| Mid arm circumference (cm) | cross-sectional measurement performed in patients who are anywhere between 6 months to 10 years post-transplant | Mid arm circumference will be measured in cm using a flexible tape measure |
Countries
United States
Outcome results
None listed