Chronic Kidney Diseases, Acute Myocardial Infarction
Conditions
Brief summary
In this study, in order to better understand the mechanism of troponin clearance and the reason for elevated troponin levels in patients with CKD, we aim to evaluate quantitatively the excretion of troponin in the urine in patients with and without CKD, and with and without myocardial injury. We will compare urinary troponin levels with blood troponin levels in these patients. In addition, we will compare the levels of hs-cTnT and hs-cTnI in the patients' sera and urine.
Detailed description
The study population will be screened at the internal wards, the nephrology ward and clinic, and the intensive cardiac care unit (ICCU) of Soroka Medical Center. It will include patients who suffer from AMI, patients with CKD with and without any cardiac disease and patients with no known renal or cardiac disease. The following information and measurements will be collected: Demographics - age, sex, weight, height. Past medical history - specifically regarding renal and cardiac diseases and procedures. Measured variables in blood serum - troponin T, troponin I, creatinine, total protein, albumin, myoglobin Measured variables in urine - troponin T, troponin I, creatinine, total protein, albumin, microalbumin, β2-microglobulin Calculations - GFR (according to MDRD equation), troponin correction to creatinine (gr troponin per gr creatinine), troponin excretion ( ), urine albumin/creatinine ratio, urine protein/creatinine ratio.
Interventions
DIAGNOSTIC_TESTBlood and urine sampling
* Blood tests - hs-cTnT, hs-cTnI, complete metabolic panel including urea, creatinine, albumin and myoglobin * Urine tests - hs-cTnT, hs-cTnI, urea, creatinine, albumin, total protein, β2-microglobulin.
Sponsors
Soroka University Medical Center
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1. Patients who are able to give informed consent. 2. Age ≥ 18
Exclusion criteria
1. Pregnant women 2. Patients after kidney transplantation. 3. Patients after heart transplantation. 4. Anuric patients.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Troponin T in blood vs. urine | 1 year | Quantitative measurements of hs-cTnT in blood and urine |
| Troponin I in blood vs. urine | 1 year | Quantitative measurements of hs-cTnI in blood and urine |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Troponin excretion in urine compared to creatinine | 1 year | Comparing urine troponin levels to urine creatinine, albumin, β2-microglobulin |
| Troponin excretion in urine compared to albumin | 1 year | Comparing urine troponin levels to urine albumin |
| Troponin excretion in urine compared to β2-microglobulin | 1 year | Comparing urine troponin levels to urine β2-microglobulin |
Countries
Israel
Outcome results
None listed