Sedation Complication
Conditions
Brief summary
The study will evaluate clinical outcomes during bronchoscopy procedures with dexmedetomidine in comparison to propofol. The clinical outcomes that will be evaluated are: oxygen saturation, transcutaneous Pco2, blood pressure and complications
Interventions
DRUGDexmedetomidine
Dexmedetomidine will be used for sedation during bronchoscopy
DRUGPropofol
Propofol
Sponsors
Rabin Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Randomised controlled trial
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* All patients in the age group 18 to 70 years requiring flexible bronchoscopic evaluation of the airway in the Pulmonary institute at Rabin medical center
Exclusion criteria
* known or suspected allergy to any of the study drugs, seizure disorder, renal (with serum creatinine \> 2 mg/dL) or hepatic impairment (elevated liver enzymes \> 2 times normal), haemodynamic instability (bradycardia with HR \< 50 bpm or hypotension with SBP \< 90 mmHg), or seriously ill patients with American Society of Anesthesiologists' physical status above III
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| number of de-saturation events | During the procedure | Number of events during bronchoscopy when saturation level decreased under 90% |
| Oxygen saturation time < 90% | During the procedure | Total time during the procedure that the oxygen saturation was under 90% |
Countries
Israel
Contacts
Primary ContactBarak Pertzov, MD
Backup ContactMordechai Kramer, MD
Outcome results
None listed