Hyperoxemia
Conditions
Brief summary
Excessive oxygen administration is known to cause oxidative stress, and absorption atelectasis. Hyperoxia is very common in general anesthesia settings. Even though there are concerns in using excessive oxygen during general anesthesia, the optimal fraction of inspired oxygen (FiO2) for general anesthesia is not well studied. The oxygen reserve index (ORI) is a parameter which can evaluate partial pressure of oxygen (PaO2) rating from 0 to 1. There are growing evidences in ORI that it might be helpful to reduce hyperoxia in critically ill patients in the intensive care unit, as well as in general anesthesia. The aim of this study is to evaluate efficacy of oxygen reserve index to reduce hyperoxemia in major abdominal surgery.
Interventions
PROCEDURETitration of fraction of inspired oxygen (FiO2) guided by SpO2
Titration of fraction of inspired oxygen (FiO2) guided by SpO2
PROCEDURETitration of fraction of inspired oxygen (FiO2) guided by ORI and SpO2
Titration of fraction of inspired oxygen (FiO2) guided by ORI and SpO2
Sponsors
Eunah Cho, MD
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Patients scheduled for elective major abdominal surgery expected to last more than 2hours. * Patients who are scheduled for invasive arterial cannulation during surgery.
Exclusion criteria
* Abnormal pulmonary function test * Pregnancy * Saturation of oxygen (SpO2) is below 92% in room air
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pressure of arterial oxygen (PaO2) after 1 hour of surgery. | After 1 hour of surgery | Pressure of arterial oxygen is obtain from arterial blood gas analysis as usual practice. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pressure of arterial oxygen (PaO2) after 2 hours of surgery. | After 2 hours of surgery | Pressure of arterial oxygen is obtain from arterial blood gas analysis as usual practice. |
| Pressure of arterial oxygen (PaO2) after 3 hours of surgery. | After 3 hours of surgery | Pressure of arterial oxygen is obtain from arterial blood gas analysis as usual practice. |
| Minimal and maximal value of PaO2 throughout the surgery | 1 hour after the end of surgery | Pressure of arterial oxygen is obtain from arterial blood gas analysis as usual practice. |
| Fraction of inspired oxygen (FiO2) | 1 hour after the end of surgery | Fraction of inspired oxygen (FiO2) administered during the surgery |
| Oxygen reserve index (ORI) | 1 hour after the end of surgery | Oxygen reserve idex shown from the monitoring device during the surgery |
Countries
South Korea
Outcome results
None listed