Cardiac Arrest
Conditions
Keywords
Heart's respiratory quotient, Cardiac Arrest, Non-invasive monitoring, Poor prognosis
Brief summary
It has been shown that elevation of the heart's respiratory quotient after cardiac surgery is predictive of the complications occurrence. In addition, a high heart's respiratory quotient is predictive of anaerobic metabolism after cardiac surgery. In the wake of cardiorespiratory arrest, the presence of anaerobic metabolism reflected by hyperlactatemia is an important prognostic factor. However, this monitoring is invasive and discontinuous. The hypothesis of the study is to show that a rise in the respiratory quotient by a non-invasive monitoring is a factor of poor prognosis in the wake of a Cardiac Arrest.
Interventions
OTHERnon invasive monitoring value
heart's respiratory quotient as non invasive monitoring value
Sponsors
University Hospital, Grenoble
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult \>18 years * Admission to intensive care unit after a non-hospital cardiopulmonary arrest. * Resumption of spontaneous cardiac activity. * Non-opposition of the patient or his relatives
Exclusion criteria
* Pregnancy * Prior neurological impairment * Persons deprived of their liberty by a judicial proceeding, or administrative decision.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Heart's respiratory value at H6 post intensive care unit admission to predict mortality | At 6 hours post intensive care unit admission | Physiological parameter |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Heart's respiratory value at H12 post intensive care unit admission to predict mortality | At 12 hours post intensive care unit admission | Physiological parameter |
| Heart's respiratory value at H24 post intensive care unit admission to predict mortality | At 24 hours post intensive care unit admission | Physiological parameter |
| Heart's respiratory value at intensive care unit admission to predict neurological prognosis | At admission of intensive care unit | Physiological parameter |
| Heart's respiratory value at H6 post intensive care unit admission to predict neurological prognosis | At 6 hours post intensive care unit admission | Physiological parameter |
| Heart's respiratory value at H12 post intensive care unit admission to predict neurological prognosis | At 12 hours post intensive care unit admission | Physiological parameter |
| Heart's respiratory value at H24 post intensive care unit admission to predict neurological prognosis | At 24 hours post intensive care unit admission | Physiological parameter |
| metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict mortality at intensive care unit admission | At admission of intensive care unit | Metabolic parameters |
| metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict mortality at H6 post intensive care unit admission | At 6 hours post intensive care unit admission | Metabolic parameters |
| Metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict mortality at H12 post intensive care unit admission | At 12 hours post intensive care unit admission | Metabolic parameters |
| Heart's respiratory value at intensive care unit admission to predict mortality | At admission of intensive care unit | Physiological parameter |
| Metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict neurological prognosis at intensive care unit admission | At admission of intensive care unit | Metabolic parameters |
| Metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict neurological prognosis at H6 post intensive care unit admission | At 6 hours post intensive care unit admission | Metabolic parameters |
| Metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict neurological prognosis at H12 post intensive care unit admission | At 12 hours post intensive care unit admission | Metabolic parameters |
| Metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict neurological prognosis at H24 post intensive care unit admission | At 24 hours post intensive care unit admission | Metabolic parameters |
| Cardiac arrest circumstances following Utstein-style guidelines according mortality | At admission of intensive care unit | Metabolic parameters |
| Cardiac arrest circumstances following Utstein-style guidelines according neurological prognosis | At admission of intensive care unit | Cardiac arrest circumstances |
| Vital status at day 30 | At 30 Days post intensive car unit admission | Alive or Dead status |
| Cerebral performance category (CPC) score at day 90 | At 90 Days post intensive car unit admission | Cerebral performance category (CPC) score : CPC=1 : Conscious, alert, and oriented with normal cognitive functions, CPC=2 : Conscious and alert with moderate cerebral disability; CPC=3: Conscious with severe disability; CPC=4: Comatose or in persistent vegetative state; CPC=5 : Certified brain death or dead by traditional criteria. |
| Metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict mortality at H24 post intensive care unit admission | At 24 hours post intensive care unit admission | Metabolic parameters |
Countries
France
Outcome results
None listed