Study of Microbiota in Longevity County, Yongfu

Study of the Feature of Intestinal Microbiota and Its Role in Healthy Aging in Southern Chinese From a Longevity County, Yongfu

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04210934

Acronym

SoMiLY

Enrollment

160

Registered

2019-12-26

Start date

2016-05-22

Completion date

2016-05-31

Last updated

2019-12-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aging, Healthy Aging

Keywords

Microbiota, multi-omics

Brief summary

This study is an observational study designed to adopt a cross-sectional study design. In the context of China's longevity town (East Asian population), Yongfu, Guangxi, the background of non-medical care and antibiotic use was explored, and the intestinal microecological balance increased with age and natural health. Longevity relationship. This study was completed using a household survey. Through routine clinical examinations and analysis of biochemical laboratory indicators, at the same time, a questionnaire for ADL(activities of daily living), cognitive function, and related elderly information was carried out on the elderly to comprehensively provide health information for each elderly. Based on the remaining stool samples and serum samples, the second-generation sequencing technology and other omics-based technologies were explored. No additional collection of human specimens and information is involved. In addition, this study also hopes to explore the transmission rules of age-related bacteria in long-lived families, and the relationship with health phenotypes such as blood sugar, blood lipids, and cognitive function. Potential impact. In summary, this study will provide data support for exploring the relationship between healthy longevity and intestinal microecological balance based on the characteristic population of the longevity hometown.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

22 Years to 111 Years

Healthy volunteers

Yes

Inclusion criteria

* Obtained informed consent signed by volunteer or guardian * Local lived for more than 50 years

Exclusion criteria

* Subjects being treated with antibiotic in 3 months * People who cannot cooperate with completing the survey * Severe gastrointestinal disorders

Design outcomes

Primary

Measure	Time frame	Description
Aging-related fecal microbiota annotation	0 week	Taxonomy of bacteria(family,genus,species),Gene of bacteria

Secondary

Measure	Time frame	Description
interface of microbiota and other biomarkers in aging and related conditions	0 week	to study the correlation between microbiota and circulating biomarkers, including metabolite, and the shifts in various aging and related conditions

Outcome results