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Decreasing Environmental Impact and Costs of Using Inhalational Anesthetic With a Carbon Dioxide Membrane Filter System

Decreasing Environmental Impact and Costs of Using Inhalational Anesthetics by Replacing Chemical Absorbers With an Innovative Carbon Dioxide Membrane Filter System - a Prospective, Randomized, Clinical Trial

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04210570
Enrollment
510
Registered
2019-12-24
Start date
2021-03-01
Completion date
2023-12-31
Last updated
2021-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia, Inhalation; Vapor

Keywords

Anesthesia, Inhalation, Vapour, CO2 Absorber, Minimal Flow Anesthesia, Memsorb, Healthcare Cost, Greenhouse gas, Environment Healthcare

Brief summary

Efficient inhalational anesthetic delivery requires the use of low-flow air and oxygen to reduce drug waste and minimize workspace contamination and environmental pollution. Currently, excess anesthetic gas is scavenged and removed from the operating room via the hospital ventilation system, where it is released into the atmosphere. CO2 is removed from the anesthesia circuit by the use of CO2 removal systems to prevent re-breathing and potential hypercarbia. Carbon dioxide is currently removed using chemical granulate absorbers (CGAs), which trap CO2 in the granules that are later disposed of when absorption capacity is reached. They require replacement approximately every other day when used in moderate to high volume surgical centres, placing a costly burden on the healthcare system and environment (landfill). One of the more concerning downfalls of using CGAs is the potential for the inhalational anesthetics to react with the granules and potentially produce toxic byproducts known as compounds A-E that are nephrotoxic and neurotoxic and require excess amounts of anesthetic gas to dilute. This excess use of anesthetics gases places a financial burden on the healthcare system and has a detrimental impact on the environment. The vast majority of the gases used are eventually released into the environment with little to no degradation where they accumulate in the troposphere and act as greenhouse gases. DMF Medical has created Memsorb, a new CO2 filtration membrane. Memsorb can remove CO2 from the anesthesia circuit without the use of CGAs, thereby eliminating the potential for toxic byproducts and allowing for significantly lower air and oxygen flow to be used, resulting in less use of inhalational anesthetics. Memsorb uses a polymeric membrane (similar to the ones used in oxygenators for cardiac surgery) that selectively allows CO2 to leave the rebreathing system, while maintaining the inhalational anesthetic in the circuit. The lifespan of Memsorb is at least 12 months, resulting in less particulate waste and a decreased cost to the healthcare system. We wish to evaluate the ability and efficacy of Memsorb in removing CO2 from the anesthesia circuit while maintaining physiologic minute volume ventilation, as compared to the traditional CGAs in a variety of surgical procedures, patient populations, and anesthesia gas flows.

Interventions

DEVICEMemsorb

Memsorb uses a polymeric membrane (similar to the ones used in oxygenators for cardiac surgery) that selectively allows CO2 to leave the rebreathing system while maintaining the inhalational anesthetic in the anesthesia circuit

DRUGChemical granulate absorber

Chemical granulate absorber trap CO2 chemically in granules that are later disposed of when absorption capacity is reached

Sponsors

Western University, Canada
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* ASA I - III * Elective surgical procedure * Laparoscopic surgery for study aim III

Exclusion criteria

* ASA \> IV * Emergency surgery * Severe respiratory disease (eg Asthma) * Raised intracranial pressure * Regional anesthesia * Absence of arterial line for study aim III * Self-reported pregnancy

Design outcomes

Primary

MeasureTime frameDescription
Effectiveness of Memsorb compared to CGA to eliminate CO2Duration of general anesthesia (up to 12 hours)etCO2 (mmHg) and tidal volumes (ml) will be measured with the two systems in GE / Dates Ohmeda anesthesia machines
Impact of Memsorb, using minimal flow anesthesia (≤ 0.50 L/min), on the amount of inhalational anesthetic (ml) used, compared to standard practiceDuration of general anesthesia (up to 12 hours)Usage of Desflurane in ml will be measured during minimal flow (≤ 0.5 L/min) anesthesia, compared to traditional higher gas flow (\> 2 L/min).
Effectiveness of using Memsorb during ventilation for removal of CO2 in laparoscopic surgeries resulting in high CO2 exposure, compared to CGAsDuration of general anesthesia (up to 12 hours)etCO2 (mmHg), paCO2 (mmHg) and tidal volumes (ml) needed remove CO2 during laparoscopic surgery, resulting in higher CO2 exposure.

Secondary

MeasureTime frameDescription
Freshgas flow during general anesthesiaDuration of general anesthesia (up to 12 hours)Measured in ml/min
Amount of inhaled anesthetics usedDuration of general anesthesia (up to 12 hours)Usage on inhaled anesthetics in ml for the surgery.
Minute volume ventilationDuration of general anesthesia (up to 12 hours)tidal volume (ml) x respiratory rate (/min)
Number of CGAs used during the study periodDuration of general anesthesia (up to 12 hours)absolute number of canisters used
Duration of anesthesiaDuration of general anesthesia (up to 12 hours)Durantion measured in minutes
Water build up in anesthesia circuitDuration of general anesthesia (up to 12 hours)Likert scale to measure water build up (1- no water, 3 - large amount of water)

Countries

Canada

Contacts

Primary ContactRuediger Noppens, MD, PhD, FRCPC
ruediger.noppens@lhsc.on.ca519) 685-8500
Backup ContactLee-Anne Focesato
LeeAnne.Fochesato@lhsc.on.ca519 685-8500

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026