Enthesitis
Conditions
Keywords
subclinical enthesitis, psoriasis, ultrasound, psoriatic arthritis
Brief summary
Detection of subclinical enthesitis by ultrasonography
Detailed description
A total of 30 patients with psoriasis and 30 age-matched healthy controls, all without musculoskeletal diseases, will be recruited. They will undergo dermatological assessment and a blinded ultrasound (US) evaluation. Clinical assessment included demographics, severity of psoriasis and musculoskeletal clinical examination. Evaluation consisted of the detection of grey scale (GS) enthesitis and Power Doppler signal in enthesis areas. The Madrid Sonography Enthesitis Index (MASEI) scoring system was used to quantify the extent of sonographic entheseal abnormalities.
Interventions
DIAGNOSTIC_TESTUltrasound
Evaluation consisted of the detection of grey scale (GS) enthesitis and Power Doppler signal in enthesis areas of participants. The Madrid Sonography Enthesitis Index (MASEI) scoring system was used to quantify the extent of sonographic entheseal abnormalities
Sponsors
Fatih Sultan Mehmet Training and Research Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Age≥18years * Patients with psoriasis without musculoskeletal symptoms * Healthy controls * No joint involvement and no clinical symptoms and signs of enthesitis and synovitis
Exclusion criteria
* Have history of gout or arthritis or peripheral neurological disease of lower extremity. * Have history of trauma and intensive sport activity in last 2 weeks. * Have received any systemic therapy (i.e. DMARD, NSAIDs, corticosteroids, immunosuppressants, retinoids or biological agents) in 3 months * Pregnant or breast-feeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Detection of Subclinical Enthesitis by Ultrasonography in Psoriasis Patients with Psoriasis and Controls: by Ultrasonography; Incidence of Psoriatic Arthritis During Within One 1 Year | 1 year. | Incidence of subclinical enthesitis,To investigate the incidence of subclinical enthesitis in patients with psoriasis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants with Risk factors of subclinical enthesitis | 1 year | To find out predictor factors of subclinical enthesitis in patients with psoriasis. To assess increase in enthesis area and PsA incidence, and show a possible relationship with baseline findings in a prospective 1-year follow-up of patients with PsO. |
Countries
Turkey (Türkiye)
Outcome results
None listed