The Effect of Curcumin for Treatment of Cancer Anorexia-Cachexia Syndrome in Patients With Stage III-IV of Head and Neck Cancer

A Double-blind, Placebo-controlled Randomized Trial Phase II Evaluating the Effect of Curcumin for Treatment of Cancer Anorexia-Cachexia Syndrome in Patients With Stage III-IV of Head and Neck Cancer

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04208334

Acronym

CurChexia

Enrollment

Registered

2019-12-23

Start date

2020-02-13

Completion date

2021-03-31

Last updated

2023-03-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer Cachexia, Head and Neck Cancer, Head and Neck Neoplasms

Keywords

Cancer cachexia, Head and neck cancer, Curcumin, Tumuric, Cancer anorexia cachexia

Brief summary

A study of Curcumin to prevent cancer anorexia and cachexia Syndrom in locally advance and advance stage head and neck cancer (stage III, IV)

Interventions

DIETARY_SUPPLEMENTCurcumin

We give an Intervention arm to consume Curcumin 4000mg/day for 60 consecutive days.

OTHERPlacebo

We give a control arm to consume placebo for 60 consecutive days.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Head and neck cancer stage III-IV * Cancer anorexia cachexia syndrome by 2011 Cancer cachexia an International Consensus * Enteral feeding with Nasogastric Tube or Gastrostomy * ECOG 0-2 * Normal Bone marrow, kidneys, and liver function * Normal function of enteral digestion and absorption

Exclusion criteria

* Pregnancy * History of allergy to Curcumin or herbal medicine * History of Herbal medicine used * History of Billiary of obstruction * History of Antiplatelete or anticoagulant.

Design outcomes

Primary

Measure	Time frame	Description
Muscle mass	60 days after intervention	We measure muscle mass by Bioelectrical Impedance Analysis (BIA)

Secondary

Measure	Time frame	Description
BMI	60 days after intervention	We measure BMI by Bioelectrical Impedance Analysis (BIA)
Hand grips muscle strength	60 days after intervention	We measure hand grips power by Hand grip test
serum NF-kB level	60 days after intervention	We measure serum NF-kB by ELISA

Countries

Thailand

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 12, 2026