Adolescent, Brain, Feeding Behavior
Conditions
Keywords
pediatric obesity, resting-state functional magnetic resonance imaging, disinhibited eating behavior
Brief summary
The brain plays an integral role in how and what people eat. However, the brain's contribution to overeating is not well understood during sensitive developmental periods such as adolescence, when excessive weight gain and obesity prevalence are a significant concern.The proposed study will use functional magnetic resonance imaging to examine how the brain's response to excess energy is related to overeating in adolescents with and without obesity.
Interventions
DIETARY_SUPPLEMENTEnergy Stimulus
Energy stimulus (energy surplus v. energy neutral) will be randomly assigned at the first brain imaging visit. At the second brain imaging visit, the participant will receive the alternate stimulus from what they received at the first brain imaging visit.
Sponsors
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
University of Colorado, Denver
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
13 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* male or female * 13-18 years-old * resident of Colorado
Exclusion criteria
* weigh less than 88 pounds or have a BMI% rank of \<10% for age and sex; * have a physician's diagnosis of metabolic syndrome or diabetes (Type 1 or 2); * have a physician's diagnosis of anorexia nervosa or bulimia nervosa; * currently taking anti-psychotic medications (not including anti-depressant or anti- anxiety medications); * have a non-MRI safe device (e.g. pacemaker or defibrillator) or metal in the body (e.g. metal pins, shrapnel); * experience symptoms of claustrophobia when in small or closed-off places; * are pregnant or plan to become pregnant
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Brain function | brain imaging visit 1 (study visit 1); 30 minutes | Brain function will be quantified via the blood oxygen level-dependent (BOLD) signal in the hypothalamus, insula, anterior cingulate cortex, nucleus accumbens, amygdala, and superior and inferior frontal gyri, and connectivity between these brain regions. |
| Disinhibited eating behavior | study visit 2; 1.5 hours | Disinhibited eating behavior will be quantified via the kilocalories consumed during the test meal phase of the Eating in the Absence of Hunger laboratory protocol. |
Countries
United States
Outcome results
None listed