Aging, Cognitive Change, Sleep Disturbance
Conditions
Keywords
dementia, depression, brain structure, system biology
Brief summary
This project aims to build up the comprehensive database of geriatric medicine for local Taiwanese.
Detailed description
This project is the pilot for the basis of establishing the schema of database and efficient procedures including subject recruitment, specimen collection, management, and measurement of samples obtained from multiple sources. We will focus on deciphering the correlation of sleep quality and the integrity of brain structure by integrating the holistic health data, socio-demographic characteristics, MRI, wearable technique, and laboratory technology including clinical lab, genotyping, metabolomics, gut microbiome, to unravel the clinical feature of which the age will effect on the frequency of sleep disturbance. This project will not only systematically study the aging effect on the sleep quality and brain structure integrity, but pave the way for exploring a variety of aging-related indications.
Interventions
None listed
Sponsors
Chang Gung University
Chang Gung Memorial Hospital
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Participants of annual health checkup conducted by either Taipei city or Chang Gung Health and Culture Village. * aged ≧ 60 years old. * have medical record in Chang Gung Memorial Hospital. * resided in the Taiwan area over 180 days in past one year.
Exclusion criteria
* Participants with the medical history of severe organ disorders, severe autoimmune disease, or cancer under treatment. * Contraindications or previously failure for receiving brain computerized tomography or magnetic resonance imaging scan. * Participants who had receive outpatient clinic follow-ups with diseases that may affect the cognitive evaluation or presentation. * Depression with ongoing diagnosis and treatment, suicide idea or suicide behavior in the past 6 months. * Difficulty in communication or disabilities
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The brain volume of local Taiwanese aged over 60 years old | one hour | Measure the volume of cerebrum, cerebellum, and skin of skull (unit in mm3) by magnetic resonance imaging (MRI) |
| The monitoring of sleep-related events of local Taiwanese aged over 60 years old | one night | Measure the sleep stages (unit in minute), apnea-hypopnea index (unit in counts/hour), and respiratory events by polysomnography |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The gut microbiota of local Taiwanese aged over 60 years old | one day | Assess the gut bacterial diversity and profile by stool analysis |
| The actigraphy of local Taiwanese aged over 60 years old | two weeks | Measure the circadian rhythm (unit in minute) by Actiwatch |
| The polysomnographic recording for elderly with obstructive sleep apnea (OSA) | three months | Subjects with OSA will undergo continuous positive airway pressure (CPAP) and evaluate the improvement rate (unit in percent) by polysomnography and sleepiness questionnaire |
| The metabolism of local Taiwanese aged over 60 years old | one day | Measure the metabolites as biomarkers by urine and blood analysis |
| The neurocognitive questionnaire of local Taiwanese aged over 60 years old | one day | Measure the neurocognitive condition and sleep quality as assessed by GDS-15, UCLA-LS, HAM-A, HAM-D, AES, TSII, CTQ, AD8, MMSE, ECog, CERAD-NAB, PSQI, ESS, SOS, and STOP-Bang |
Countries
Taiwan
Contacts
Primary ContactJI-TSENG FANG, M.D.
Outcome results
None listed