Arthropathy, Hemophilia, Osteopenia
Conditions
Brief summary
The investigators propose, as part of the study, to carry out for each patient: * An analysis of monocytic populations by flow cytometry (CD14, CD16, CD45, CD68, CD115, CCR2, CX3CR1, CD163 and CD206). * A population assessment of Myeloid-Derived Suppressor Cells (MDSC). * Assays of cytokines and chemokines involved in inflammation by multiplex analyzes: Il-1 (α and β), Il-4, Il-6, Il-10, Il-13, TNF- α, TGF- β, CRP , leptin, IFN- β. * Specialized dosages of proteins involved in bone metabolism. RANKL, osteoprotegerin, M-CSF, TRAPCP5.
Interventions
OTHERObservational study
Observational study
Sponsors
Nantes University Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Major patients followed at the hemophilia treatment reference center, * Presenting the diagnosis of severe, moderate or minor Hemophilia A / B, * Having a social security system, * Obtaining the oral non-objection collection from the patient after information.
Exclusion criteria
* Minor patients, under guardianship or curatorship. * Causes of secondary osteoporosis: * Systemic corticosteroid therapy in progress (≥ 3 consecutive months, at a dosage ≥ 7.5 mg / d of prednisone equivalent). * other treatment or condition responsible for osteoporosis: prolonged or medicated hypogonadism, untreated active hyperthyroidism, hypercorticism, primary hyperparathyroidism. * Treatment with biphosphonates, biotherapies or hormone therapy in the treatment of prostate cancer.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To study the monocytic populations possibly involved in bone metabolism in hemophiliac patients. | 1 year | Evaluation of the inflammatory profile of patients by protein assays |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Find a correlation between the main objective and the measurement of bone density | 1 year | Evaluation of biochemical parameters involved in bone metabolism |
| Look for a correlation between the main objective and physical activity | 1 year | Assessment of physical activity by self-questionnaire |
| Look for a correlation between the main objective and the inflammatory profile in hemophiliac patients. | 1 year | Evaluation of the inflammatory profile of patients by protein assays |
Countries
France
Outcome results
None listed