Obesity, Overweight
Conditions
Brief summary
Study design The study was designed as a prospective controlled randomized trial. Participants were randomly assigned to one of two groups. In the experimental group, participants (n = 17) received 8-week aerobic exercise intervention without nutrition modifications. In the control group, participants (n = 16) did not undergo any intervention and were instructed to maintain their regular physical activity and diet regime for 8 weeks. Experimental measurements: Anthropometric measurements, Measurement of BDNF, Cardiac autonomic responses, Measurement of aerobic fitness, Measurement of cognitive functions.
Interventions
OTHERAerobic exercise
8-week aerobic exercise (moderate intensity), 5 times per week, 60 min per session. Exercise training under supervision of trained staff.
Sponsors
Lithuanian Sports University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
38 Years to 56 Years
Healthy volunteers
Yes
Inclusion criteria
1. obese women (BMI) \> 25 kg/m2; 2. exhibiting weight stability (body weight change \< 2 kg) for at least 2 months prior to enrollment; 3. with a sedentary lifestyle (regular exercise \< 1 h/week); 4. had no medical condition that would affect study results and limit physical activity; 5. not undergoing lactation; 6. who were not pregnant or postmenopausal.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Weight | 8 weeks | weight (TBF-300 body composition scale; Tanita, UK Ltd., UK) was measured while the participants wore only underwear and were barefoot. |
| Blood brain-derived neurotrophic factor (BDNF) | 8 weeks | Venous blood samples (5 mL) were collected and allowed to clot at room temperature. Serum was then separated by centrifugation for 15 min at 1,200 g (room temperature) and stored at -80°C until analysis. BDNF were measured using an enzyme-linked immunoassay system (Gemini; Stratec Biomedical, Birkenfeld, Germany). |
| Cognitive performance | 8 weeks | Automated Neuropsychological Assessment Metrics Version 4 (ANAM-4; Vista Life, USA) was used to measure neurocognitive skills: motor reaction time, mental flexibility, mathematical processing, working memory, visual scanning and associative learning skills. Participants were familiarized with the test battery twice before the experiments. |
| Maximal oxygen uptake | 8 weeks | Aerobic fitness was assessed by a graded exercise test on an electronically braked cycle ergometer (Ergoselect 100, Ergoline, Bitz, Germany). Standardized verbal encouragement was provided throughout the test to stimulate maximal performance. |
| Waist and hip circumference | 8 weeks | Waist circumference was measured to the nearest 0.1 cm, in duplicate, at the level of the iliac crest at the end of the normal expiration. Hip circumference was measured at the maximum protuberance of the buttocks. Waist and hip circumferences were measured at the nearest 0.5 cm. |
| Resting blood pressure | 8 weeks | was measured using a digital electronic blood pressure monitor (Microlife BP A100, Widnau, Switzerland) |
| Heart rate variability | 8 weeks | R-R intervals were recorded using a Polar H7 sensor with a chest strap (Kempele, Finland). |
Countries
Lithuania
Outcome results
None listed