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Screening Strategy for Early Diagnosis of Silicosis in At-Risk Populations in Oklahoma

Screening Strategy for Early Diagnosis of Silicosis in At-Risk Populations in Oklahoma

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04205708
Enrollment
183
Registered
2019-12-19
Start date
2019-01-14
Completion date
2022-06-10
Last updated
2023-12-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pneumoconiosis; Silica, Silicosis

Keywords

silica, public health, early prevention, silicosis, screening, Oklahoma, lung disease, pulmonology, Pneumoconiosis, lung, dust exposure, occupational health, community health

Brief summary

Silicosis, a preventable yet irreversible occupational lung disease, has an insidious onset with a latency period for diagnosis extending beyond 10 years from the initial exposure. The central hypothesis of this study is that silicosis cases may currently be going undetected. The long-term goal of this research is to determine the current prevalence and forecast the future prevalence of silicosis and other pneumoconiosis among working populations in Oklahoma and to assist the public health and the healthcare system in planning for a potential resurgence of silicosis.

Interventions

DIAGNOSTIC_TESTTuberculosis test

Tuberculosis (TB) test: A blood sample is collected for lab testing to determine if you have tuberculosis (QuantiFeron test). Alternatively, the test is done by injecting a small amount of fluid (called tuberculin) into the skin on the lower part of the arm. A person given the tuberculin skin test must return within 48 to 72 hours to have a trained health care worker look for a reaction on the arm.

DIAGNOSTIC_TESTChest X-ray

Chest X ray: non-invasive medical test that helps physicians diagnose and treat medical conditions of the lungs and chest. The Chest X-ray will be done to check for abnormalities on the lungs. The test is non-invasive.

DIAGNOSTIC_TESTPulmonary Function Test

A pulmonary function test (PFT, spirometry) is a breathing test that measures how much air your lungs can hold as well as how hard and fast you can blow air out of your lungs. The test is not invasive and involves blowing into a machine.

Sponsors

University of Oklahoma
Lead SponsorOTHER

Study design

Observational model
ECOLOGIC_OR_COMMUNITY
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
30 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Male 30 years or older * Past or present employment in dusty environment, exposed to dust at work * Ability to consent and answer the questionnaire

Exclusion criteria

* Female * Never exposed to dusty environment or never exposed to dust at work * Inability to consent and answer the questionnaire * Age 29 years or younger

Design outcomes

Primary

MeasureTime frameDescription
Estimate of average cumulative respirable crystalline silica exposure (semi-quantitative)Single point assessment at baseline surveyEstimate of average cumulative respirable crystalline silica exposure (semi-quantitative)
Percentage of participants who report any exposure to silicaSingle point assessment at baseline surveyPercentage of participants who report any exposure to silica
Prevalence of silicosis among study groupSingle point assessment at clinic visitPercentage of participants with confirmed diagnosis of silicosis

Secondary

MeasureTime frameDescription
Analysis to determine if any demographic, work history, or other trait correlates with increased silica exposureSingle point assessment at baseline surveyAnalysis to determine if any demographic, work history, or other trait correlates with increased silica exposure

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026