FTO Gene Variants and Diet in Obesity

Impact of FTO Gene Variants and Lifestyle Factors on Obesity Traits in a Turkish Population

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04205318

Enrollment

400

Registered

2019-12-19

Start date

2017-03-01

Completion date

2018-12-31

Last updated

2019-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diet Habit, Genetic Predisposition, Obesity

Keywords

obesity, gene-diet interaction, FTO gene variant

Brief summary

Studies have shown that the effect of fat mass and obesity-associated (FTO) gene on obesity is modulated by lifestyle factors. Hence, we aimed to determine whether two single nucleotide polymorphisms (SNPs) in the FTO gene are associated with obesity and to assess whether these associations were modified by lifestyle factors. The study included 200 obese and 200 non-obese individuals from Turkey. Our study suggests that the effect of the SNPs on obesity traits is likely to be influenced by lifestyle factors in this Turkish population.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

24 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

1. attending routine outpatient visits, 2. aged 24 to 50 years, 3. having a BMI ≥ 18.50 kg/m2

Design outcomes

Primary

Measure	Time frame	Description
Genetic analysis of two SNPs at FTO gene	up to 36 weeks	FTO SNPs rs9939609 and rs10163409
Anthropometric measurements	up to 36 weeks	Body mass index, waist circumference, hip circumference, body composition
Biochemical measurements	up to 36 weeks	lipid profile, glucose, insulin, adiponectin

Countries

Turkey (Türkiye)

Outcome results