Gastric Cancer
Conditions
Brief summary
The primary purpose is to compare the remifentanil requirements in deep vs moderate neuromuscular blocks during the surgical pleth index -guided anesthesia in patients undergoing laparoscopic gastrectomy.
Interventions
DRUGNeostigmine + glycopyrate
maintaining of moderate neuromuscular block (train-of-four count 1-2) during surgery, reversal using neostigmine 50 ug/kg and glycopyrrolate 10 ug/kg
DRUGSugammadex
maintaining of deep neuromuscular block (posttetanic count 1-2) during surgery, reversal using sugammadex 2-4 mg/kg
Sponsors
Ajou University School of Medicine
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
19 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Clinical diagnosis of gastric cancer Scheduled laparoscopic gastrectomy
Exclusion criteria
* Patients refusal to consent Hyperbilirubinemia Chronic pain Opioid abuse Incurrent infective status Peripheral vascular disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| total dose of remifentanil | from pneumoperitoneum to removal of laparoscope | remifentanil infusion using target effect-site concentration to achieve an surgical pleth index of range between 20 and 50 |
Countries
South Korea
Outcome results
None listed