Epileptic Seizures
Conditions
Keywords
Status epilepticus, Electroencephalogram
Brief summary
The aim of this observational multicenter cohort study is to gain a deeper understanding regarding the effects of treatment adaption based on information from outcome prediction models, risk stratification, as well as treatment monitoring, detection, prevention, and management of complications on course and outcome of adult patients with status epilepticus (SE).
Interventions
Extract data from the digital medical records, the electroencephalographic and microbiologic database.
Sponsors
University Hospital, Basel, Switzerland
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult patients (i.e., patients ≥18 years of age) with diagnosed SE between 2005 and 2023 who have been treated at the University Hospital of Basel or the Cantonal Hospital Aarau.
Exclusion criteria
* Patients younger than 18 years. * Patients with repetitive epileptic seizures not qualifying for SE. * Patients with documented refusal of the general consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Demographics | between 01.01.2005 and 31.12.2023 | age, sex |
| Data from acute prehospital management by the emergency medical services (EMS) | between 01.01.2005 and 31.12.2023 | extracted from the treatment protocols of the EMS |
| Duration of ICU (intensive care unit) and hospital stay, and destination at discharge | between 01.01.2005 and 31.12.2023 | Duration of ICU (intensive care unit) and hospital stay, and destination at discharge |
| Date(s) of seizure(s) captured by electroencephalographic (EEG) data | between 01.01.2005 and 31.12.2023 | Date(s) of seizure(s) captured by EEG |
| Seizure history and etiology | between 01.01.2005 and 31.12.2023 | withdrawal from anti seizure drugs, structural, infectious, or autoimmune causes |
| Number and Duration of SE episodes | between 01.01.2005 and 31.12.2023 | Number and Duration (time) of SE episodes |
| Types of SE | between 01.01.2005 and 31.12.2023 | Types of SE according to the current guidelines from the International League of Epilepsy (ILAE) (i.e., nonconvulsive with coma, SE with motor symptoms, focal nonconvulsive SE without coma, and subtle SE |
| Additional features of the seizure | between 01.01.2005 and 31.12.2023 | length, level of consciousness at onset, previous epileptic seizures |
| ICU Scoring Systems | between 01.01.2005 and 31.12.2023 | Critical illness severity scores (e.g., acute physiology and chronic health Evaluation (APACHE II), simplified acute physiology score (SAPS II), sequential organ failure assessment (SOFA), etc.) |
| Clinical neurologic monitoring scores | between 01.01.2005 and 31.12.2023 | Clinical neurologic monitoring scores (e.g., Richmond Agitation-Sedation Scale (RASS) , Seda-tion-Agitation Scale (SAS), Glasgow Coma Score (GCS), Intensive Care Delirium Screening Checklist (ICDSC), Status Epilepticus Severity Score (STESS)) |
| Laboratory parameters | between 01.01.2005 and 31.12.2023 | C-Reactive Protein (CRP), albumin, Lactate Dehydrogenase (LDH), Creatin-Kinase (CK), procalcitonin, white blood cell levels, creatinine, liver enzymes, blood gas analyses, metabolic data |
| Outcome measure | between 01.01.2005 and 31.12.2023 | in-hospital death, survival, survival with neurofunctional alteration, Glasgow Outcome Score, return to neurofunctional premorbid baseline, readmission |
| Therapeutic features | between 01.01.2005 and 31.12.2023 | duration, dosage and number of treatment medication, number of antiseizure drugs, invasive procedures, such as intubation, mechanical, ventilation, vasopressors, installation of central lines, nutrition |
| Monitoring of vital signs | between 01.01.2005 and 31.12.2023 | blood pressure, heart rate, respiratory rate, oxygen saturation of the blood, body temperature, level of consciousness |
Countries
Switzerland
Contacts
CONTACTRaoul Sutter, PD Dr. med
CONTACTSaskia Semmlack, Dr. med
PRINCIPAL_INVESTIGATORRaoul Sutter, PD Dr. med
Clinic for Intensive Care Medicine, University Hospital Basel
Outcome results
None listed