Polypharmacy
Conditions
Keywords
Deprescribing
Brief summary
Deprescribing, the process of safely reducing or discontinuing unnecessary or harmful medication, has the potential to decrease polypharmacy and improve health outcomes. In this study a structured implicit algorithm, focusing on both extrinsic medication factors (eg change in disease) and intrinsic patient factors (eg. pill burden) will be used.
Interventions
OTHERDeprescribing algorithm
For this study an implicit, evidence-supported and patient-centred algorithm has been developed. The outcome of the algorithm is an advice to the doctor to deprescribe or not deprescribe the statin and/or PPI.
Sponsors
Zuyderland Medisch Centrum
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Intervention model description
A multicentre, unblinded, single group (pre-comparison and post-comparison) feasibility study.
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Participant uses a statin and/or a proton pump inhibitor. * Participant signs informed consent. * Participant is a nursing home resident.
Exclusion criteria
* Participant is there for short term nursing home admission (\<3 months) * Participant is there for hospice admission.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Decrease in pill burden (the number of statins and PPI's) | 3 and 6 months after intervention. | On T0 (intervention) and on T1 + T2 (3 and 6 months after intervention), we will measure the number of PPI's and statins on the medication list of every participant. These are provided by the pharmacist. |
| Decrease in pill burden (the dose of statins and PPI's) | 3 and 6 months after intervention. | On T0 (intervention) and on T1 + T2 (3 and 6 months after intervention), we will measure the dose of PPI's and statins on the medication list of every participant. These are provided by the pharmacist. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| All possible negative side effects of deprescribing (e.g. nausea, symptom recurrence) | From intervention to six months after intervention | All possible negative effects of deprescribing as recognised by the doctor involved, e.g. symptom recurrence. |
| Feasibility to use this algorithm. | 3 and 6 months after intervention | Three and six months after intervention we will ask the participating doctors the next questions (per included participant): * What did the algorithm advice you? * Did you follow the advice? * Why dit you follow/deny the advice? |
Countries
Netherlands
Outcome results
None listed