Vaginal Flora Imbalance
Conditions
Brief summary
Vaginal flora is closely related to female reproductive health. Previous studies have suggested that the composition of the vaginal flora is related to the pregnancy outcomes, and abnormalities in the vaginal flora lead to a decrease in the success rate of IVF. During the IVF treatment, the hormone level changes far exceed the physiological level. What changes will happen to the vaginal flora? Does IVF treatment itself affect the vaginal flora and affect outcomes? This study used prospective cohort study to show the changes in vaginal flora during conventional IVF treatment, providing more evidence for revealing the relationship between vaginal flora and infertility treatment outcomes.
Interventions
PROCEDUREIVF/ICSI
ovarian stimulation ，vaginal disinfection of flushing
Sponsors
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* 20-40 years old * BMI\<30kg/m2 * First IVF/ICSI cycle (GnRH agonist or antagonist protocol) * no vaginitis after recruitment * completion of oocyte retrieval
Exclusion criteria
* history of RSA * history of endometriosis * Immune diseases such as SLE, etc., and the use of immunosuppressive agents, glucocorticoids, etc. * obvious hydrosalpinx(\>2cm in diameter by ultrasound)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| clinical pregnancy rate | 12.2019-03.2020 | no. of clinical pregnancy / total number of embryo transfer cycles |
Countries
China
Contacts
Primary ContactHaiyan Lin, Doctor
Outcome results
None listed