Multiple Sclerosis, Neuromyelitis Optica
Conditions
Brief summary
The aim of this study was the describe the Immunologic biomarker profile of cerebrospinal fluid in multiple sclerosis patients
Interventions
OTHERBiomarker analysis
Detection of biomarker in cerebrospinal fluid
Sponsors
Centre Hospitalier Universitaire de Nīmes
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* patients who have had neuromyelitis ptica with anti-AQP4 antibodies, or anti- Myelin Oligodendrocyte Glycoprotein antibodies, or double seronegative antibodies. * Neuromyelitis Optica patients have been prospectively included in the OFSEP collection * Multiple sclerosis patients, isolated myelitis or optic neuritis patients, and symptomatic controls whose samples will come from the NEURO collection of the Hospital Biological Collections Center, * Patients have given their free consent for use of their samples in research
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Level of soluble vascular cell adhesion molecule-1 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein | Baseline | enzyme-linked immunosorbent assay |
| Level of glial fibrillar acidic protein in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein | Baseline | enzyme-linked immunosorbent assay |
| Level of chitinase-3-like protein 1 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein | Baseline | enzyme-linked immunosorbent assay |
| Level of neurofilament in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein | Baseline | enzyme-linked immunosorbent assay |
| Level of Interleukin-6 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein | Baseline | enzyme-linked immunosorbent assay |
| Level of Interleukin-8 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein | Baseline | enzyme-linked immunosorbent assay |
| Level of C-X-C motif ligand (CXCL-13) in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein | Baseline | enzyme-linked immunosorbent assay |
| Level of Matrix metalloproteinase-9 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein | Baseline | enzyme-linked immunosorbent assay |
| Level of Soluble CD27 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein | Baseline | enzyme-linked immunosorbent assay |
| Level of Interleukin 10 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein | Baseline | enzyme-linked immunosorbent assay |
| Level of Interleukin 17A in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein | Baseline | enzyme-linked immunosorbent assay |
| Level of Interleukin 1B in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein | Baseline | enzyme-linked immunosorbent assay |
| Level of monocyte chemoattractant protein-1 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein | Baseline | enzyme-linked immunosorbent assay |
| Level of soluble intercellular adhesion molecule-1 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein | Baseline | enzyme-linked immunosorbent assay |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Level of soluble intercellular adhesion molecule-1 in cerebrospinal fluid in each group | Baseline | enzyme-linked immunosorbent assay |
| Level of soluble vascular cell adhesion molecule-1 in cerebrospinal fluid in each group | Baseline | enzyme-linked immunosorbent assay |
| Level of glial fibrillar acidic protein in cerebrospinal fluid in each group | Baseline | enzyme-linked immunosorbent assay |
| Level of chitinase-3-like protein 1 in cerebrospinal fluid in each group | Baseline | enzyme-linked immunosorbent assay |
| Level of neurofilament in cerebrospinal fluid in each group | Baseline | enzyme-linked immunosorbent assay |
| Level of Interleukin-6 in cerebrospinal fluid in each group | Baseline | enzyme-linked immunosorbent assay |
| Level of Interleukin-8 in cerebrospinal fluid in each group | Baseline | enzyme-linked immunosorbent assay |
| Level of C-X-C motif ligand (CXCL-13) in cerebrospinal fluid in each group | Baseline | enzyme-linked immunosorbent assay |
| Level of Matrix metalloproteinase-9 in cerebrospinal fluid in each group | Baseline | enzyme-linked immunosorbent assay |
| Level of Soluble CD27 in cerebrospinal fluid in each group | Baseline | enzyme-linked immunosorbent assay |
| Level of Interleukin 10 in cerebrospinal fluid in each group | Baseline | enzyme-linked immunosorbent assay |
| Level of Interleukin 17A in cerebrospinal fluid in each group | Baseline | enzyme-linked immunosorbent assay |
| Level of Interleukin 1B in cerebrospinal fluid in each group | Baseline | enzyme-linked immunosorbent assay |
| Level of monocyte chemoattractant protein-1 in cerebrospinal fluid in each group | Baseline | enzyme-linked immunosorbent assay |
Countries
France
Outcome results
None listed