Bleeding Disorder, Disorder of Blood Gas
Conditions
Keywords
Arterial blood gas, Coagulation, Nitrogen compounds
Brief summary
The aim of the study was to investigate the possible relationship about blood gas and bleeding disorders in healthy volunteers of blasters and no blasters groups of the Italian National Mountain and Cave Rescue who handled nitrogen compounds and nitroglycerine and then they were exposed to combustion products from an accidental uncontrolled detonation of micro-charges during a cave unblocking procedure.
Detailed description
This was a field report of clinical data collected during an accidental uncontrolled detonation of micro-charges, while the cave unblocking procedure was performed by volunteers of blaster group and non blasters group of the Italian National Mountain and Cave Rescue, in a cave in Trieste (Italy; altitude entrance: 348 meters above sea level; total length: 413,5 meters; total depth of 307 meters). Before going into the cave (Time 0), the following clinical data were collected: age, sex, body mass index; smoke (yes/no), heart rate, arterial blood pressure (mean arterial pressure), oxygen saturation measured with pulse oxymetry, epitympanic temperature, blood gases analyses and the haemostasis measures. After the accidental uncontrolled detonation of micro-charges, (Time 1) heart rate, arterial blood pressure, oxygen saturation measured with pulse oxymetry, epitympanic temperature, blood gases analyses and the haemostasis measures were recorded in each volunteers.
Interventions
DIAGNOSTIC_TESTArterial blood gas analyses and haemostasis measures
Under aseptic conditions, a puncture of radial artery was performed: three mL of the arterial blood sample were used for the haemostasis measure, while one mL was tested for the blood gases analysis.
Sponsors
Emiliano Petrucci
Study design
Observational model
CASE_CONTROL
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy volunteers of Italian National Mountain and Cave Rescue
Exclusion criteria
* gas exchange disorders * quantitative abnormalities of coagulation assessment * qualitative abnormalities of coagulation assessment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline arterial blood gases analysis at 2 hours | 10 minutes before going in to the cave and two hours after the volunteers come out from the cave | Under aseptic conditions, a puncture of radial artery was performed: one mL was tested for the blood gases analysis, by using i-STAT analyser. |
| Change from baseline haemostasis analysis at 2 hours | 10 minutes before going in to the cave and two hours after the volunteers come out from the cave | Under aseptic conditions, a venipuncture was performed: three mL of blood sample were used for the haemostasis measure, by using Rotational Thromboelastometry |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from Baseline heart rate at 2 hours | 10 minutes before going in to the cave and two hours after the volunteers come out from the cave | Haert rate was recorded by using a multiparametric monitor |
| Change from baseline arterial blood pressure at 2 hours | 10 minutes before going in to the cave and two hours after the volunteers come out from the cave | Arterial blood pressure was recorded by using a multiparametric monitor |
| Change from baseline pulse oxymetry at 2 hours | 10 minutes before going in to the cave and two hours after the volunteers come out from the cave | Pulse oxymetry was recorded by using a multiparametric monitor |
| Change from baseline epitympanic temperature at 2 hours | 10 minutes before going in to the cave and two hours after the volunteers come out from the cave | Epitympanic temperature was measured by using epitympanic probe |
Countries
Italy
Outcome results
None listed