Food Allergy Peanut
Conditions
Brief summary
Use of three intralymphatic injections of peanut allergen one month apart to induce tolerance to peanut in peanut allergic people.
Detailed description
Eligible subject undergo a baseline blinded oral peanut challenge. Then the peanut ILIT as described above. Pretreatment with antihistamines, leukotriene modifier and albuterol before each treatment. Following the three ILIT peanut injections a repeat blinded oral peanut challenge is performed. Blood is drawn at each of the 5 study visits for a variety of tests trying to elucidate the mechanism(s) of the induction of tolerance to peanut.
Interventions
BIOLOGICALPeanut allergen
Intralymphatic immunotherapy injections.
Sponsors
The Scripps Research Institute
Scripps Health
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
All subjects receive the study intervention: Peanut ILIT.
Eligibility
Sex/Gender
ALL
Age
15 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
History of peanut allergy Positive prick skin tests or invitro IgE to peanut Positive blinded oral peanut challenge. \-
Exclusion criteria
History of * life threatening anaphylaxis to peanut Uncontrolled asthma
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Peanut tolerance | 4 months | Increase in amount (mg - grams) of peanut ingested without reaction from baseline to one month post ILIT |
Countries
United States
Outcome results
None listed