Coronary Occlusion
Conditions
Keywords
Quantitative Flow Ratio, QFR, Percutaneous Coronary Intervention
Brief summary
Prospective intervention study to assess the accuracy of the predicted QFR-derived virtual angioplasty compared to hyperaemic and non-hyperaemic pressure-wire derived indexes after PCI, as well as with QFR post-PCI.
Interventions
DIAGNOSTIC_TESTQuantitative Flow Ratio (QFR) measurement
Quantitative flow ratio (QFR) is a novel approach enabling rapid computation of FFR pullbacks from three-dimensional quantitative coronary angiography (3D-QCA) without using a pressure wire.
Sponsors
Hospital Clínico Universitario de Valladolid
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients submitted to a coronary angiogram with at least one non-left main stable coronary stenosis with PCI indication.
Exclusion criteria
* Severe stenosis of the left main coronary artery. * Patients admitted with ST-elevation myocardial infarction. * Culprit lesions in Non-ST-Elevation Acute Coronary Syndromes (NSTEACS) patients. * Unability to identify the culprit lesion in NSTE-ACS patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Numerical agreement between predicted post PCI QFR (residual QFR) and post PCI dPR RFR-FFR, as well as direct QFR post-PCI mesurement. | 1 hour |
Secondary
| Measure | Time frame |
|---|---|
| Sensitivity | 1 hour |
| Specificity | 1 hour |
| Summary of the receiver-operator characteristics curve (sROC) | 1 hour |
| Negative predictive value | 1 hour |
| Positive predictive value | 1 hour |
| Positive likelihood ratio | 1 hour |
| Negative likelihood ratio | 1 hour |
| Identification of independent predictors for increased predicted postPCI QFR (residual QFR) and post PCI dPR-RFR-FFR. | 1 hour |
Countries
Spain
Contacts
Primary ContactCarlos Baladron, PhD
Outcome results
None listed