Clinical and Radiographic Evaluation of Advanced Platelet Rich Fibrin in the Preservation of Alveolar Ridge Following Atraumatic Tooth Extraction

Clinical and Radiographic Evaluation of Advanced Platelet Rich Fibrin in the Preservation of Alveolar Ridge Following Atraumatic Tooth Extraction: A Randomized Clinical Trial

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04197895

Enrollment

Registered

2019-12-13

Start date

2020-01-01

Completion date

2020-12-20

Last updated

2019-12-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Socket Preservation

Brief summary

compare the effect of application of A-PRF in socket preservation after atraumatic tooth extraction and natural healing regarding to bone remodeling . Null hypotheis, after atraumatic extraction, socket with advanced PRF has no difference with socket with blood clot in primary outcome

Interventions

PROCEDURESocket preservation with APRF

Socket preservation with APRF , A-PRF membranes were implanted into the extraction socket following tooth extraction. One entire A-PRF membrane would be placed at the base of the extraction socket and another A-PRF membrane will cover the extraction site then suturing will be done .Venous blood will be collected via venipuncture of the forearm with a butterfly needle into at least 10 mL sterile glass vacuum tube. The blood sample will be immediately centrifuged at 1,300 rpm (200 x g) for 8 minutes

PROCEDUREnatural healing

after atraumatic extraction , the socket will be left for natural healing after suturing

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* The inclusion criteria are as follow : * patients with an unremarkable medical history * subjects with at least one site bordered by minimum of one tooth. * Nonsmoker * Teeth with root fracture, teeth with failed endodontic therapy or advanced caries * Intact extraction socket with no dehiscence or fenestration. * The buccolingual thickness of the buccal plate of bone in surgical area is 1 mm or more

Exclusion criteria

* Patients with systemic diseases. * Patients with presence or history of osteonecrosis of the jaws, with use of bisphosphonates, exposure to head and neck radiation, chemotherapy. * patients with large distinct pre-apical pathology

Design outcomes

Primary

Measure	Time frame	Description
mesial and distal height of extraction site	2 months	digital radiograph

Secondary

Measure	Time frame	Description
soft tissue thickness	2 months	will be evaluated by endo file with rubber stopper and digital caliper

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026