Day 3 Fresh Transfer Followed by Day 3 or Day 5 Vitrification of Supernumerary Embryos

Cumulative Pregnancy Rates and Direct Healthcare Cost Analysis of Two Different Strategies: Fresh Cleavage-stage Embryo Transfer (ET) on Day 3 With Vitrification of Supernumerary Embryos on Day 3 Versus Day 5

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04196036

Enrollment

150

Registered

2019-12-12

Start date

2018-01-15

Completion date

2021-12-30

Last updated

2022-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Subfertility

Brief summary

This monocenter academic study aims to evaluate the effectiveness and cost effectiveness of two different strategies: fresh Embryo Transfer (ET) on day 3 followed by cryopreservation of cleavage-stage (Day 3) embryos versus blastocyst-stage (Day 5) embryos. The primary outcome is the cumulative pregnancy rate after all transfers (fresh and/or frozen embryo transfer cycles which might take about 1 year), up to two sequential cycles. The secondary outcome concerns a cost analysis of both strategies from the healthcare payer's perspective.

Interventions

PROCEDUREDay of vitrification

Supernumerary embryos after fresh transfer on Day 3 after oocyte aspiration are either vitrified on Day 3 or are kept in culture until Day 5 and vitrified on Day 5

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 37 Years

Healthy volunteers

Inclusion criteria

* subfertile women planned for the first or second oocyte retrieval for in vitro fertilisation (IVF)/Intracytoplasmic sperm injection (ICSI) treatment * who are older than 18 and less than 38 years old * who have normal Follicle Stimulating Hormone (FSH) and normal Anti-Mullerian Hormone (AMH) levels

Exclusion criteria

* treatment with donor oocytes or donor embryos * patients planned for Pre-implantation Genetic Diagnosis (PGD) * Patients with BMI\>30 * patients with endometriosis grade III-IV

Design outcomes

Primary

Measure	Time frame	Description
cumulative pregnancy rate	Cumulative pregnancy is measured after two consecutive IVF cycles including fresh and frozen transfers which might take about 1 year	The cumulative pregnancy rate after all transfers (fresh and/or frozen embryo transfer cycles)

Secondary

Measure	Time frame	Description
cost analysis	Cumulative pregnancy is measured after two consecutive IVF cycles including fresh and frozen transfers which might take about 1 year	cost analysis of day 3 and day 5 vitrification strategy

Countries

Belgium

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 12, 2026