Myopia
Conditions
Brief summary
The objective of the study was to compare the clinical performance of the two contact lenses when used in combination with three care systems.
Detailed description
This was a randomized, open-label, crossover study, controlled by cross-comparison. Subjects were randomized to wear each lens and solution combination for a month in random sequence; that is for a total of six months.
Interventions
DEVICEcomfilcon A
Subjects were randomized to wear each lens and solution combination for a month.
DEVICEfanfilcon A
Subjects were randomized to wear each lens and solution combination for a month.
Sponsors
CooperVision, Inc.
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Subjects will use each lens and solution combination for a month in random sequence for a total of six months.
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
1. They are aged 18-50 and have capacity to volunteer. 2. They understand their rights as a research subject and are willing and able to sign a Statement of Informed Consent. 3. They are willing and able to follow the protocol. 4. They are an existing wearer of reusable, single vision, spherical soft contact lenses. 5. They have a contact lens spherical prescription between -1.00 to - 6.50D (inclusive) 6. They have a spectacle cylindrical correction of -1.00D or less in each eye. 7. At dispensing, they can attain at least 0.20 logMAR distance high contrast visual acuity in each eye with the study lenses within the available power range. 8. They are willing to comply with the wear schedule (at least five days per week and for at least eight hours per day). 9. They agree not to participate in other clinical research for the duration of the study.
Exclusion criteria
1. They have an ocular disorder which would normally contra-indicate contact lens wear. 2. They have a systemic disorder which would normally contra-indicate contact lens wear. 3. They are using any topical medication such as eye drops or ointment. 4. They have had cataract surgery. 5. They have had corneal refractive surgery. 6. They have any corneal distortion resulting from previous hard or rigid lens wear or have keratoconus. 7. They are pregnant or breastfeeding. 8. They have any ocular abnormality which would, in the opinion of the investigator, normally contraindicate contact lens wear. 9. They have any infectious disease which would, in the opinion of the investigator, contraindicate contact lens wear or pose a risk to study personnel; or they have any immunosuppressive disease (e.g. HIV), or a history of anaphylaxis or severe allergic reaction. 10. They have taken part in any other contact lens or care solution clinical trial or research, within two weeks prior to starting this study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Overall Comfort | One Month | Overall Comfort will be assessed using vertical visual analogue scales (0-100) (0 - Causes Pain. Cannot be tolerated, 20 -Very uncomfortable, very irritating or annoying, 40 - Slightly uncomfortable, just irritating or annoying, 60 - Comfortable. Noticeable but not irritating, 80 - Very comfortable. Just felt occasionally, 100 - Excellent. Cannot be felt). |
| Comfort on Insertion | One Month | Comfort on insertion will be assessed using vertical visual analogue scales (0-100) (0 - Causes Pain. Cannot be tolerated, 20 -Very uncomfortable, very irritating or annoying, 40 - Slightly uncomfortable, just irritating or annoying, 60 - Comfortable. Noticeable but not irritating, 80 - Very comfortable. Just felt occasionally, 100 - Excellent. Cannot be felt). |
| Comfort Before Removal | One Month | Comfort before removal will be assessed using vertical visual analogue scales (0-100) (0 - Causes Pain. Cannot be tolerated, 20 -Very uncomfortable, very irritating or annoying, 40 - Slightly uncomfortable, just irritating or annoying, 60 - Comfortable. Noticeable but not irritating, 80 - Very comfortable. Just felt occasionally, 100 - Excellent. Cannot be felt). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Dryness | One Month | Dryness will be assessed using vertical visual analogue scales (0-100) (0 - Extremely poor. Intolerable levels of dryness, 20 - Very poor. Dryness which definitely affects wearing my contact lenses, 40 - Poor. A level of dryness which is sometimes annoying, 60 - Good. Acceptable level of dryness, 80 - Very good. Very occasional or very slight sensation of dryness only, 100 - Excellent. I have no sensation of dryness whatsoever). |
| Ocular Redness | One Month | Ocular Redness will be assessed using vertical visual analogue scales (0-100) (0 - Extremely poor. Intolerable levels of redness, 20 - Very poor. Excessive redness which definitely affects wearing my contact lenses, 40 - Poor. A level of redness which is sometimes annoying, 60 - Good. Acceptable level of redness, 80 - Very good. Very occasional or very slight awareness of redness, 100 - Excellent. No redness). |
| Vision | One Month | Vision will be assessed using vertical visual analogue scales (0-100) (0 - Unacceptable. Lens cannot be worn, 20 - Very poor. Marked and unacceptable reduction, 40 - Poor. Noticeable but acceptable reduction, 60 - Good. Occasional but acceptable reduction, 80 - Very good. Just noticeable and very occasional reduction, 100 -Excellent. Unaware of any visual loss) |
| Ease of Lens Insertion | One Month | Ease of lens insertion will be assessed using vertical visual analogue scales 0-100. (0 - Unmanageable. Lenses impossible to insert, 20 - Very poor. Difficult and occasional unsuccessful insertion, 40 - Poor. Difficult with very occasional unsuccessful insertion, 60 - Good. Some problems but lens insertion usually successful, 80 - Very good. Occasional difficulty with lens insertion, 100 - Excellent. No problems with lens insertion). |
| Ease of Lens Removal | One Month | Ease of lens removal will be assessed using vertical visual analogue scales (0-100) ( 0 - Unmanageable. Lenses impossible to remove, 20 - Very poor. Difficult and occasional unsuccessful removal, 40 - Poor. Difficult with very occasional unsuccessful removal, 60 - Good. Some problems but lens removal usually successful, 80 - Very good. Occasional difficulty with lens removal, 100 - Excellent. No problems with lens removal). |
| Burning/Stinging | One Month | Burning/Stinging will be assessed using vertical visual analogue scales (0-100) (0 - Extremely poor. Intolerable levels of burning or stinging, 20 - Very poor. Excessive burning or stinging which definitely affects wearing my contact lenses, 40 - Poor. A level of burning or stinging which is sometimes annoying, 60 - Good. Acceptable level of burning or stinging, 80 - Very good. Very occasional or very slight sensation of burning or stinging, 100 - Excellent. No burning or stinging). |
| Variable Vision | One Month | Variable Vision will be assessed using vertical visual analogue scales (0-100) (0 - Extremely poor. Intolerable levels of variation in vision, 20 - Very poor. Excessive variation in vision which definitely affects wearing my contact lenses, 40 - Poor. A level of variation in vision which is sometimes annoying, Good. Acceptable level of variation in vision, 80 - Very good. Very occasional or very slight sensation of variation in vision, 100 - Excellent. No variation in vision). |
| Vision at Night | One Month | Vision at night will be assessed using vertical visual analogue scales (0-100) (0 - Unacceptable. Lens cannot be worn, 20 - Very poor. Marked and unacceptable reduction, 40 - Poor. Noticeable but acceptable reduction, 60 - Good. Occasional but acceptable reduction, 80 - Very good. Just noticeable and very occasional reduction, 100 -Excellent. Unaware of any visual loss) |
Countries
United Kingdom
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Overall Study Subjects were randomized to use each lens and solution combination for a month in random sequence; that is for a total of six months. Lenses (comfilcon A and fanfilcon A), Lens care solutions(Hy-Care, All in One Light and Refine One Step). | 33 |
| Total | 33 |
Withdrawals & dropouts
| Period | Reason | FG000 |
|---|---|---|
| Comfilcon A With All in One Light | Withdrawal by Subject | 4 |
| Comfilcon A With Hy-Care | Withdrawal by Subject | 5 |
| Comfilcon A With Refine One Step | Withdrawal by Subject | 1 |
| Fanfilcon A With All in One Light | Withdrawal by Subject | 1 |
| Fanfilcon A With Hy-Care | Withdrawal by Subject | 3 |
| Fanfilcon A With Refine One Step | Withdrawal by Subject | 2 |
Baseline characteristics
| Characteristic | Overall Study | — |
|---|---|---|
| Age, Categorical <=18 years | 0 Participants | — |
| Age, Categorical >=65 years | 0 Participants | — |
| Age, Categorical Between 18 and 65 years | 33 Participants | — |
| Age, Continuous | 28.3 years STANDARD_DEVIATION 7.4 | — |
| Race and Ethnicity Not Collected | — | — Participants |
| Region of Enrollment United Kingdom | 33 participants | — |
| Sex: Female, Male Female | 29 Participants | — |
| Sex: Female, Male Male | 4 Participants | — |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk | EG002 affected / at risk | EG003 affected / at risk | EG004 affected / at risk | EG005 affected / at risk |
|---|---|---|---|---|---|---|
| deaths Total, all-cause mortality | 0 / 30 | 0 / 28 | 0 / 25 | 0 / 28 | 0 / 28 | 0 / 29 |
| other Total, other adverse events | 2 / 30 | 0 / 28 | 0 / 25 | 2 / 28 | 1 / 28 | 2 / 29 |
| serious Total, serious adverse events | 1 / 30 | 0 / 28 | 0 / 25 | 0 / 28 | 1 / 28 | 0 / 29 |
Outcome results
Primary
Comfort Before Removal
Comfort before removal will be assessed using vertical visual analogue scales (0-100) (0 - Causes Pain. Cannot be tolerated, 20 -Very uncomfortable, very irritating or annoying, 40 - Slightly uncomfortable, just irritating or annoying, 60 - Comfortable. Noticeable but not irritating, 80 - Very comfortable. Just felt occasionally, 100 - Excellent. Cannot be felt).
Time frame: One Month
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Comfilcon A With All in One Light Multi-purpose Solution | Comfort Before Removal | 80.0 units on a scale | Standard Deviation 17.2 |
| Comfilcon A With Hy-Care Multi-purpose Solution | Comfort Before Removal | 72.8 units on a scale | Standard Deviation 17.8 |
| Comfilcon A With Refine One Step Hydrogen Peroxide Solution | Comfort Before Removal | 74.2 units on a scale | Standard Deviation 19.9 |
| Fanfilcon A With All in One Light Multi-purpose Solution | Comfort Before Removal | 79.1 units on a scale | Standard Deviation 17.2 |
| Fanfilcon A With Hy-Care Multi-purpose Solution | Comfort Before Removal | 82.4 units on a scale | Standard Deviation 14.2 |
| Fanfilcon A With Refine One Step Hydrogen Peroxide Solution | Comfort Before Removal | 76.1 units on a scale | Standard Deviation 19.9 |
Primary
Comfort on Insertion
Comfort on insertion will be assessed using vertical visual analogue scales (0-100) (0 - Causes Pain. Cannot be tolerated, 20 -Very uncomfortable, very irritating or annoying, 40 - Slightly uncomfortable, just irritating or annoying, 60 - Comfortable. Noticeable but not irritating, 80 - Very comfortable. Just felt occasionally, 100 - Excellent. Cannot be felt).
Time frame: One Month
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Comfilcon A With All in One Light Multi-purpose Solution | Comfort on Insertion | 88.3 units on a scale | Standard Deviation 12.7 |
| Comfilcon A With Hy-Care Multi-purpose Solution | Comfort on Insertion | 85.8 units on a scale | Standard Deviation 15 |
| Comfilcon A With Refine One Step Hydrogen Peroxide Solution | Comfort on Insertion | 84.0 units on a scale | Standard Deviation 17.1 |
| Fanfilcon A With All in One Light Multi-purpose Solution | Comfort on Insertion | 88.6 units on a scale | Standard Deviation 14.9 |
| Fanfilcon A With Hy-Care Multi-purpose Solution | Comfort on Insertion | 90.3 units on a scale | Standard Deviation 10.6 |
| Fanfilcon A With Refine One Step Hydrogen Peroxide Solution | Comfort on Insertion | 87.3 units on a scale | Standard Deviation 11.8 |
Primary
Overall Comfort
Overall Comfort will be assessed using vertical visual analogue scales (0-100) (0 - Causes Pain. Cannot be tolerated, 20 -Very uncomfortable, very irritating or annoying, 40 - Slightly uncomfortable, just irritating or annoying, 60 - Comfortable. Noticeable but not irritating, 80 - Very comfortable. Just felt occasionally, 100 - Excellent. Cannot be felt).
Time frame: One Month
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Comfilcon A With All in One Light Multi-purpose Solution | Overall Comfort | 86.0 units on a scale | Standard Deviation 12 |
| Comfilcon A With Hy-Care Multi-purpose Solution | Overall Comfort | 81.6 units on a scale | Standard Deviation 14.9 |
| Comfilcon A With Refine One Step Hydrogen Peroxide Solution | Overall Comfort | 81.0 units on a scale | Standard Deviation 17.1 |
| Fanfilcon A With All in One Light Multi-purpose Solution | Overall Comfort | 87.7 units on a scale | Standard Deviation 11.7 |
| Fanfilcon A With Hy-Care Multi-purpose Solution | Overall Comfort | 88.0 units on a scale | Standard Deviation 9.5 |
| Fanfilcon A With Refine One Step Hydrogen Peroxide Solution | Overall Comfort | 82.7 units on a scale | Standard Deviation 16.7 |
Secondary
Burning/Stinging
Burning/Stinging will be assessed using vertical visual analogue scales (0-100) (0 - Extremely poor. Intolerable levels of burning or stinging, 20 - Very poor. Excessive burning or stinging which definitely affects wearing my contact lenses, 40 - Poor. A level of burning or stinging which is sometimes annoying, 60 - Good. Acceptable level of burning or stinging, 80 - Very good. Very occasional or very slight sensation of burning or stinging, 100 - Excellent. No burning or stinging).
Time frame: One Month
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Comfilcon A With All in One Light Multi-purpose Solution | Burning/Stinging | 93.4 units on a scale | Standard Deviation 13.1 |
| Comfilcon A With Hy-Care Multi-purpose Solution | Burning/Stinging | 90.6 units on a scale | Standard Deviation 14.7 |
| Comfilcon A With Refine One Step Hydrogen Peroxide Solution | Burning/Stinging | 85.7 units on a scale | Standard Deviation 16.4 |
| Fanfilcon A With All in One Light Multi-purpose Solution | Burning/Stinging | 92.4 units on a scale | Standard Deviation 14.3 |
| Fanfilcon A With Hy-Care Multi-purpose Solution | Burning/Stinging | 95.7 units on a scale | Standard Deviation 7.8 |
| Fanfilcon A With Refine One Step Hydrogen Peroxide Solution | Burning/Stinging | 89.6 units on a scale | Standard Deviation 14.8 |
Secondary
Dryness
Dryness will be assessed using vertical visual analogue scales (0-100) (0 - Extremely poor. Intolerable levels of dryness, 20 - Very poor. Dryness which definitely affects wearing my contact lenses, 40 - Poor. A level of dryness which is sometimes annoying, 60 - Good. Acceptable level of dryness, 80 - Very good. Very occasional or very slight sensation of dryness only, 100 - Excellent. I have no sensation of dryness whatsoever).
Time frame: One Month
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Comfilcon A With All in One Light Multi-purpose Solution | Dryness | 85.5 units on a scale | Standard Deviation 18.2 |
| Comfilcon A With Hy-Care Multi-purpose Solution | Dryness | 81.4 units on a scale | Standard Deviation 17.4 |
| Comfilcon A With Refine One Step Hydrogen Peroxide Solution | Dryness | 81.5 units on a scale | Standard Deviation 20.5 |
| Fanfilcon A With All in One Light Multi-purpose Solution | Dryness | 86.6 units on a scale | Standard Deviation 11.3 |
| Fanfilcon A With Hy-Care Multi-purpose Solution | Dryness | 86.3 units on a scale | Standard Deviation 12.7 |
| Fanfilcon A With Refine One Step Hydrogen Peroxide Solution | Dryness | 83.3 units on a scale | Standard Deviation 16.3 |
Secondary
Ease of Lens Insertion
Ease of lens insertion will be assessed using vertical visual analogue scales 0-100. (0 - Unmanageable. Lenses impossible to insert, 20 - Very poor. Difficult and occasional unsuccessful insertion, 40 - Poor. Difficult with very occasional unsuccessful insertion, 60 - Good. Some problems but lens insertion usually successful, 80 - Very good. Occasional difficulty with lens insertion, 100 - Excellent. No problems with lens insertion).
Time frame: One Month
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Comfilcon A With All in One Light Multi-purpose Solution | Ease of Lens Insertion | 93.5 units on a scale | Standard Deviation 9 |
| Comfilcon A With Hy-Care Multi-purpose Solution | Ease of Lens Insertion | 91.2 units on a scale | Standard Deviation 9.7 |
| Comfilcon A With Refine One Step Hydrogen Peroxide Solution | Ease of Lens Insertion | 91.7 units on a scale | Standard Deviation 12.4 |
| Fanfilcon A With All in One Light Multi-purpose Solution | Ease of Lens Insertion | 91.6 units on a scale | Standard Deviation 14.1 |
| Fanfilcon A With Hy-Care Multi-purpose Solution | Ease of Lens Insertion | 92.9 units on a scale | Standard Deviation 9.7 |
| Fanfilcon A With Refine One Step Hydrogen Peroxide Solution | Ease of Lens Insertion | 91.3 units on a scale | Standard Deviation 11.9 |
Secondary
Ease of Lens Removal
Ease of lens removal will be assessed using vertical visual analogue scales (0-100) ( 0 - Unmanageable. Lenses impossible to remove, 20 - Very poor. Difficult and occasional unsuccessful removal, 40 - Poor. Difficult with very occasional unsuccessful removal, 60 - Good. Some problems but lens removal usually successful, 80 - Very good. Occasional difficulty with lens removal, 100 - Excellent. No problems with lens removal).
Time frame: One Month
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Comfilcon A With All in One Light Multi-purpose Solution | Ease of Lens Removal | 92.1 units on a scale | Standard Deviation 13.7 |
| Comfilcon A With Hy-Care Multi-purpose Solution | Ease of Lens Removal | 92.2 units on a scale | Standard Deviation 12.6 |
| Comfilcon A With Refine One Step Hydrogen Peroxide Solution | Ease of Lens Removal | 91.6 units on a scale | Standard Deviation 14 |
| Fanfilcon A With All in One Light Multi-purpose Solution | Ease of Lens Removal | 90.9 units on a scale | Standard Deviation 10.7 |
| Fanfilcon A With Hy-Care Multi-purpose Solution | Ease of Lens Removal | 92.0 units on a scale | Standard Deviation 11.6 |
| Fanfilcon A With Refine One Step Hydrogen Peroxide Solution | Ease of Lens Removal | 89.7 units on a scale | Standard Deviation 12.5 |
Secondary
Ocular Redness
Ocular Redness will be assessed using vertical visual analogue scales (0-100) (0 - Extremely poor. Intolerable levels of redness, 20 - Very poor. Excessive redness which definitely affects wearing my contact lenses, 40 - Poor. A level of redness which is sometimes annoying, 60 - Good. Acceptable level of redness, 80 - Very good. Very occasional or very slight awareness of redness, 100 - Excellent. No redness).
Time frame: One Month
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Comfilcon A With All in One Light Multi-purpose Solution | Ocular Redness | 96.2 units on a scale | Standard Deviation 8.6 |
| Comfilcon A With Hy-Care Multi-purpose Solution | Ocular Redness | 92.6 units on a scale | Standard Deviation 13.7 |
| Comfilcon A With Refine One Step Hydrogen Peroxide Solution | Ocular Redness | 94.2 units on a scale | Standard Deviation 10.9 |
| Fanfilcon A With All in One Light Multi-purpose Solution | Ocular Redness | 95.8 units on a scale | Standard Deviation 8.9 |
| Fanfilcon A With Hy-Care Multi-purpose Solution | Ocular Redness | 96.0 units on a scale | Standard Deviation 5.6 |
| Fanfilcon A With Refine One Step Hydrogen Peroxide Solution | Ocular Redness | 92.7 units on a scale | Standard Deviation 9.3 |
Secondary
Variable Vision
Variable Vision will be assessed using vertical visual analogue scales (0-100) (0 - Extremely poor. Intolerable levels of variation in vision, 20 - Very poor. Excessive variation in vision which definitely affects wearing my contact lenses, 40 - Poor. A level of variation in vision which is sometimes annoying, Good. Acceptable level of variation in vision, 80 - Very good. Very occasional or very slight sensation of variation in vision, 100 - Excellent. No variation in vision).
Time frame: One Month
Population: One subject was excluded from the analysis from fanfilcon A with All in One Light multipurpose solution and fanfilcon A with Refine One Step Hydrogen Peroxide Solution.
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Comfilcon A With All in One Light Multi-purpose Solution | Variable Vision | 92.5 units on a scale | Standard Deviation 9.5 |
| Comfilcon A With Hy-Care Multi-purpose Solution | Variable Vision | 92.0 units on a scale | Standard Deviation 11.5 |
| Comfilcon A With Refine One Step Hydrogen Peroxide Solution | Variable Vision | 91.8 units on a scale | Standard Deviation 13.2 |
| Fanfilcon A With All in One Light Multi-purpose Solution | Variable Vision | 89.8 units on a scale | Standard Deviation 15.4 |
| Fanfilcon A With Hy-Care Multi-purpose Solution | Variable Vision | 92.8 units on a scale | Standard Deviation 9.5 |
| Fanfilcon A With Refine One Step Hydrogen Peroxide Solution | Variable Vision | 92.8 units on a scale | Standard Deviation 10.9 |
Secondary
Vision
Vision will be assessed using vertical visual analogue scales (0-100) (0 - Unacceptable. Lens cannot be worn, 20 - Very poor. Marked and unacceptable reduction, 40 - Poor. Noticeable but acceptable reduction, 60 - Good. Occasional but acceptable reduction, 80 - Very good. Just noticeable and very occasional reduction, 100 -Excellent. Unaware of any visual loss)
Time frame: One Month
Population: One subject was excluded from the analysis from fanfilcon A with All in One Light multipurpose solution and fanfilcon A with Refine One Step Hydrogen Peroxide Solution.
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Comfilcon A With All in One Light Multi-purpose Solution | Vision | 94.8 units on a scale | Standard Deviation 7.7 |
| Comfilcon A With Hy-Care Multi-purpose Solution | Vision | 91.4 units on a scale | Standard Deviation 11.9 |
| Comfilcon A With Refine One Step Hydrogen Peroxide Solution | Vision | 93.3 units on a scale | Standard Deviation 9.3 |
| Fanfilcon A With All in One Light Multi-purpose Solution | Vision | 90.9 units on a scale | Standard Deviation 13.1 |
| Fanfilcon A With Hy-Care Multi-purpose Solution | Vision | 94.2 units on a scale | Standard Deviation 7.7 |
| Fanfilcon A With Refine One Step Hydrogen Peroxide Solution | Vision | 93.4 units on a scale | Standard Deviation 10.1 |
Secondary
Vision at Night
Vision at night will be assessed using vertical visual analogue scales (0-100) (0 - Unacceptable. Lens cannot be worn, 20 - Very poor. Marked and unacceptable reduction, 40 - Poor. Noticeable but acceptable reduction, 60 - Good. Occasional but acceptable reduction, 80 - Very good. Just noticeable and very occasional reduction, 100 -Excellent. Unaware of any visual loss)
Time frame: One Month
Population: One subject was excluded from the analysis from fanfilcon A with All in One Light multipurpose solution and fanfilcon A with Refine One Step Hydrogen Peroxide Solution.
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Comfilcon A With All in One Light Multi-purpose Solution | Vision at Night | 92.5 units on a scale | Standard Deviation 9.4 |
| Comfilcon A With Hy-Care Multi-purpose Solution | Vision at Night | 89.4 units on a scale | Standard Deviation 13.8 |
| Comfilcon A With Refine One Step Hydrogen Peroxide Solution | Vision at Night | 91.6 units on a scale | Standard Deviation 12.5 |
| Fanfilcon A With All in One Light Multi-purpose Solution | Vision at Night | 89.8 units on a scale | Standard Deviation 13 |
| Fanfilcon A With Hy-Care Multi-purpose Solution | Vision at Night | 91.3 units on a scale | Standard Deviation 9.2 |
| Fanfilcon A With Refine One Step Hydrogen Peroxide Solution | Vision at Night | 91.4 units on a scale | Standard Deviation 11 |