Spinal Osteochondrosis
Conditions
Brief summary
The present study is proposed for the identification of phenotype, biochemical and genetic markers in adult symptomatic spinal osteochondrosis to promote the early diagnosis of this pathological condition and to establish possible therapeutic targets that favor a conservative approach aimed at treating patients.
Detailed description
The primary outcome is to determine the association between specific phenotypic characteristics of osteochondrosis, in particular linked to osteo-cartilaginous degeneration, with the identified vitamin D receptor genotypes. The secondary outcomes are to evaluate the circulating levels of the osteo-cartilage degradation markers, of the vitamin D and to evaluate the association of the osteochondrosis phenotype with variants in genes involved in inflammatory processes.
Interventions
GENETICpresence of genetic variants
identification of the presence of genetic variants
Sponsors
I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* males and females * 18≤age ≤ 65 years old * patients with adult spinal osteochondrosis
Exclusion criteria
* age \< 18 or \> 65 years old * chronic major diseases such as diabetes, autoimmune diseases, cardiovascular diseases, malignancies
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| association of spinal osteochondrosis with specific VDR genotypes | 1st year | Determine the association between specific phenotypic characteristics of osteochondrosis identified by means of MRI, in particular the presence of wavy/Irregular, notched endplates or Shmorl's nodes with FokI, BsmI, ApaI, TaqI VDR genotypes, assessed by means of TaqMan SNP Genotyping Assays |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| association of spinal osteochondrosis with specific biochemical markers | 2nd year | Determine the association between specific phenotypic characteristics of osteochondrosis identified by means of MRI, in particular the presence of wavy/Irregular, notched endplates or Shmorl's nodes with the circulating levels of the osteo-cartilage degradation markers CTx-I, CTx-II and of the vitamin D. |
Other
| Measure | Time frame | Description |
|---|---|---|
| association of spinal osteochondrosis with specific inflammatory genotypes | 1st year | Exploratory evaluation of the association of the osteochondrosis phenotype with variants in genes involved in inflammatory processes, such as IL-1B and IL-1RN. |
Countries
Italy
Contacts
Primary ContactAlessandra Colombini
Backup ContactElena Cittera
Outcome results
None listed