ART
Conditions
Brief summary
During assisted reproduction technology treatments like in vitro fertilization, some patients give a poor ovarian response to controlled ovarian hyperstimulation. The European Society of Human Reproduction and Embryology consensus defined poor response to ovarian stimulation during in vitro fertilization with Bologna criteria. Bologna criteria: At least two of the following three features must be present: (i) Advanced maternal age (≥40 years). (ii) Previous Poor responders (≤3 oocytes with a conventional stimulation protocol). (iii) An abnormal ovarian reserve test Most controlled ovarian hyperstimulation regimens currently used for expected poor responders are based on using a high daily dose (300- 450 IU/day) of exogenous gonadotropins. Giving a high gonadotropin dose obviously increases the cost of in vitro fertilization, a consequence that would be acceptable if paralleled by an improvement in in vitro fertilization outcome. Unfortunately, however, the available data suggest that increasing the daily gonadotropins dose may increase the number of retrieved oocytes, but not the final success rate of in vitro fertilization.
Interventions
DRUGLetrozole
Oral tablet letrozole 2,5 mg/twice daily for 5 days
DRUGMenotropins
150 IU of highly purified menotropins intramuscular
DRUGrecombinant Follicular stimulating hormone
recombinant Follicular stimulating hormone 300- 400 IU
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
40 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* Advanced maternal age (≥40 years) . * Previous Poor responders (≤3 oocytes with a conventional stimulation protocol). * An abnormal ovarian reserve tests
Exclusion criteria
* Hyper or Normal responders patients. * Endocrine or metabolic diseases like hyperprolactinoma, hypothyroidism,...etc * Patients with a severe male factor abnormality. 4-Patients with systemic disease such as chronic renal disease, chronic liver disease, etc
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total gonadotrophins dose | 14 days |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Duration of ovarian stimulation | 14 days | — |
| Endometrial thickness | 14 days | by ultrasounds |
Countries
Egypt
Outcome results
None listed