Oral Lichen Planus
Conditions
Keywords
pomegranate, seeds, peel, topical, Oral lichen planus, pain, OHIP-14.
Brief summary
This study was conducted to estimate the hypothesis that the Pomegranate Extracts have no role in management of oral lichen planus
Detailed description
Lichen planus is a common chronic mucocutaneous disease of uncertain origin that has been shown to affect 0.5% to 2.2% of various populations. The treatment options for OLP are numerous and include topical and systemic agents. Steroids were found effective in management of OLP with contraindicated use in some systemic diseases and with multiple side effects with its prolonged use. Pomegranates have been known for hundreds of years for their multiple health benefits, including anti-inflammatory activity. The recent surge indicates that pomegranates and their extracts may serve as natural alternatives to drugs which can offer a possible management of OLP decreasing pain and discomfort associated with this chronic condition.The aim of this study was the evaluation of the effect of topical pomegranate extracts in management of oral lichen planus lesions (OLP).
Interventions
DRUGTopical pomegranate seeds and peel extracts
Topical pomegranate seeds and peel extracts in the form of gel
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Caregiver, Outcomes Assessor)
Masking description
The clinical outcomes were assessed by an investigator masked about the treatment modality that has been used
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* The study inclusion criteria were patients of both sexes with 18 to 60 years old in age with atrophic type OLP and signed the informed consent
Exclusion criteria
* Patients who excluded from the study were smokers, pregnant, lactating ladies and patients under topical and systemic steroids during the last two months. Uncontrolled diabetic patients or hypertension in addition to hepatic and cardiac patients were not included. In addition, any previous history of allergy to pomegranate
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| visual analog scale (VAS) | 4 weeks | Pain assessment scale |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Sign score | 4 weeks | Score for clinical improvement of the signs |
| OHIP-14 questionnaire | 4 weeks | evaluate the oral health related quality of life |
Countries
Egypt
Outcome results
None listed