LPP , MP and DP:Relation With Mortality and SOFA in Mechanically Ventilated Patients in ER, Ward and ICU

Relation of Pulmonary Protective Ventilation, Mechanical Power and Driving Pressure With Mortality and SOFA of Mechanically Ventilated Patients in ER, Ward and ICU at General Hospital 11 IMSS Piedras Negras, Coahuila

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04193254

Acronym

LUMEDRI-MORT

Enrollment

Registered

2019-12-10

Start date

2019-09-01

Completion date

2020-03-01

Last updated

2020-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Driving Pressure, Lung Protective Ventilation, Mechanical Power, Mechanical Ventilation Complication

Keywords

lung protective ventilation, mechanical power, driving pressure, SOFA

Brief summary

Prospective, observational, longitudinal study, September 2019 to March 2020 of all adult patients who required invasive mechanical ventilation treated at General Hospital of Zone 11 IMSS in Piedras Negras, Coahuila. The investigators aim to assess the relation of lung protective ventilation, mechanical power and driving pressure in mortality and SOFA of mechanically ventilated patients inside and outside ICU at the General Hospital of Zona 11 Piedras Negras, IMSS

Detailed description

Prospective, observational, longitudinal study from Sept 2019 to Feb 2020 of all adult patients who required invasive mechanical ventilation treated at General Hospital of Zone 11 IMSS in Piedras Negras Coahuila. Independent variable: Lung protective ventilation, Mechanical power, Driving pressure Dependent variable: Hospital Mortality, Sequential Organic Failure Assessment (SOFA) Also will be registered: 1. Primary diagnosis 2. Compliance with lung protective ventilation 3. Complications associated to mechanical ventilation 4. Quality of attention indicators for MV patients as defined by Semicyuc. 5. Real mortality vs Expected mortality analysis

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients with 18 years or older, with invasive mechanical ventilation

Exclusion criteria

* Patients with 17 years or younger

Design outcomes

Primary

Measure	Time frame	Description
Correlation of Lung protective ventilation with mortality and SOFA (Sequential Organic Failure Assessment)	Sept 19-Feb 20	Lung Protective Ventilation: Qualitative variable will be defined as YES or NO with the averages of the daily measurements of tidal volume and Pressure plateau. It is defined as Tidal volume (Vc or Vt) \<8 ml / kg (ideal weight) and Plateau or plateau pressure (Ppl, Pm) \<30cmH2O
Correlation of mechanical power with mortality and SOFA	Sept 19-Feb 20	Mechanical power: Quantitative variable. calculated using Marinni equation: MP= (0.098)x(Plateau pressure-PEEP)x Respiratory Rate xTidal Volume. Normal range \< 13
Correlation of driving pressure with mortality and SOFA	Sept 19-Feb 20	Driving Pressure: Quantitative variabel, calculated using: Pplateau pressure-PEEP. nomral range \< 13

Countries

Mexico

Outcome results