Prolonged Vasospasm in Subarachnoid Hemorrhage

Clinical Implication of Prolonged Vasospasm in Subarachnoid Hemorrhage

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04193124

Acronym

PVE

Enrollment

109

Registered

2019-12-10

Start date

2015-04-30

Completion date

2019-12-31

Last updated

2019-12-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Subarachnoid Hemorrhage, Vasospasm, Intracranial

Keywords

Subarachnoid Hemorrhage, Vasospasm, Intracranial, Transcranial doppler

Brief summary

The prevalence and clinical implications of prolonged cerebral vasospasm in patients with subarachnoid hemorrhage are unknown.

Detailed description

The prevalence and clinical importance of prolonged cerebral vasospasm (after day 21 of bleeding) in patients with subarachnoid hemorrhage is unknown. Objectives: To determine the prevalence and clinical relevance of prolonged vasospasm in patients with subarachnoid hemorrhage secondary to cerebral aneurysm. A prospective and observational study was conducted. Adult patients with a diagnosis of subarcnoid hemorrhage CT scan or presence of blood in the cerebrospinal fluid were incorporated. Patients with vasospasm were followed daily with transcranial doppler. Those with technical impossibility to perform transcranial and pregnant Doppler were excluded. Day 0 was defined, the day of the last bleeding. Evaluation: 1) It was considered in patients with prolonged vasospasm: whether or not it was associated with clinical manifestation (deterioration of the sensory or new neurological deficit) and 2) the magnitude of the vasospasm (mild, moderate or severe) was measured by transcranial doppler.

Interventions

DIAGNOSTIC_TESTtranscranial doppler.

Daily monitoring of transcranial doppler until the disappearance of the intracranial vasosparm

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Subarachnoid hemorrhage -

Exclusion criteria

Pregnancy \-

Design outcomes

Primary

Measure	Time frame	Description
Clinical implication	1 month	Presence or not of neurological symptoms related to intracranial vasospasm (delayed cerebral ischemia)
Gravity of vasospasm by transcranial doppler	1 month	Mild, moderate and severe according to Aaslid scale

Secondary

Measure	Time frame	Description
Mortality assessment	six monts	Mortality was assessed at hospital discharge and at six months

Other

Measure	Time frame	Description
Neurological recovery	six monts	Neurological recovery at six months according to Glasgow outcome scale

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026