Sudden Hearing Loss, Obstructive Sleep Apnea
Conditions
Brief summary
This clinical randomized controlled study is to explore the effect of positive airway pressure(PAP) on patients in Beijing Tsinghua Changgung Hospital diagnosed with both idiopathic sudden sensorineural hearing loss comorbided(ISSHL) and obstructive sleep apnea(OSA) between Dec. 2019 to Dec. 2029.
Interventions
DEVICEnon-invasive positive airway pressure
non-invasive positive airway pressure is the first-line treatment for obstructive sleep apnea
Methylprednisolone is the first-line treatment of idiopathic sudden sensorineural hearing loss
DRUGGinaton
ginnaton is ginkgo biloba extract
Sponsors
Beijing Tsinghua Chang Gung Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
1. aged \>= 18 and \<= 70, 2. diagnosed with OSA by full-night in-lab or home-stay PSG according to AASM 2012 criteria, and AHI \> 15/h, 3. diagnosed with ISSHL by AAO-HNS 2019 criteria, 4. ISSHL onset within 1 week.
Exclusion criteria
1. sudden hearing loss with certain causes, 2. with severe comorbid diseases, 3. pregnant or breast-feeding women, 4. AHI \<= 15/h, 5. hearing threshold recovered \> 50% when included, 6. previously regularly treated with PAP.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| hearing threshold | 3 months after onset of ISSHL | the recovery of hearing threshold which will be measured by pure tone audiometry |
Countries
China
Contacts
Primary ContactJingying Ye, MD
Backup ContactHaijin Yi, MD
Outcome results
None listed